14. E3 Ring Finger Ubiquitin ligases: Structure and Drug Design
14. C.T. Chasapis, G.A. Spyroulias. E3 Ring Finger Ubiquitin ligases: Structure and Drug Design. Curr. Pharm. Design 31, 3716-3731 (2009).
Group’s Publications in peer-reviewed scientific journals since 2006:
13. Folding in Solution of the C – Catalytic Protein Fragment of Angiotensin Converting Enzyme
13. S.-S.M. Vamvakas, L. Leondiadis, G. Pairas, E. Manessi-Zoupa, G.A. Spyroulias, P. Cordopatis. Folding in Solution of the C – Catalytic Protein Fragment of Angiotensin Converting Enzyme. J. Pept. Sci. 15, 504-510 (2009). 10.1002/psc.1151
12. Insights into the anthrax lethal factor-substrate interaction and selectivity using docking and molecular dynamics simulations
12. G.A. Dalkas, A. Papakyriakou, A. Vlamis-Gardikas, G.A. Spyroulias. Insights into the anthrax lethal factor-substrate interaction and selectivity using docking and molecular dynamics simulations. Protein Science 18, 1774-1785 (2009). 10.1002/pro.169
11. NMR evidence of charge-dependent interaction between various PND V3 and CCR5 N-terminal peptides
11. P.A. Galanakis, N.G. Kandias, A. Rizos, D. Morikis, E. Krambovitis, G.A. Spyroulias. NMR evidence of charge-dependent interaction between various PND V3 and CCR5 N-terminal peptides. Biopolymers – Peptide Science 92, 94-109 (2009). 10.1002/bip.21127
10. High yield expression, and NMR characterization of Arkadia E3 Ubiquitin Ligase RING-H2 finger domain
10. N.G. Kandias, C.T. Chasapis, V. Episkopou, D. Bentrop, G.A. Spyroulias. High yield expression, and NMR characterization of Arkadia E3 Ubiquitin Ligase RING-H2 finger domain. BBRC 378, 498-502 (2009). 10.1016/j.bbrc.2008.11.055
9. Mechanism of CuA assembly
9. L. A. Abriata, L. Banci, I. Bertini, S. Ciofi-Baffoni, P. Gkazonis, G.A. Spyroulias, A.J. Vila, S. Wang. Mechanism of CuA assembly. Nature Chemical Biology 4, 599-601 (2008). 10.1038/nchembio.110
8. Soluble guanylyl cyclase (sGC) activation by HMR-1766 (ataciguat) in cells exposed to oxidative stress
8. Z. Zhou, A. Pyriochou, A. Kotanidou, G.A. Dalkas, M. van Eickels, G.A. Spyroulias, C. Roussos A. Papapetropoulos. Soluble guanylyl cyclase (sGC) activation by HMR-1766 (ataciguat) in cells exposed to oxidative stress. American Journal of Physiology – Heart & Circulatory Physiology 295, Η1763-1771 (2008).10.1152/ajpheart.51.2008
7. Three isoforms of Complement Properdin Factor P in trout. Cloning, Expression, Gene Organization and Constrained Modeling. Dev. Comp. Immunol. 12, 1454-1466 (2008)
7. M. Chondrou, A.D. Papanastasiou, G.A. Spyroulias, I.K. Zarkadis. Three isoforms of Complement Properdin Factor P in trout. Cloning, Expression, Gene Organization and Constrained Modeling. Dev. Comp. Immunol. 12, 1454-1466 (2008). 10.1016/j.dci.2008.06.010
6. Low molecular weight inhibitors of the protease Anthrax Lethal Factor
6. G. Dalkas, A.Papakyriakou, A. Vlamis-Gardikas, G.A. Spyroulias. Low molecular weight inhibitors of the protease Anthrax Lethal Factor. Mini Reviews in Medicinal Chemistry 8, 290-306 (2008). 10.2174/138955708783744083
5. Pyrrolo[2,3-a]carbazoles as potential CDK1 inhibitors. Synthesis, preliminary biological evaluation and binding mode through docking simulations
5. M. A. Fousteris,A. Papakyriakou,A. Koutsourea, M. Manioudaki, E. Lampropoulou, E. Papadimitriou,G.A. Spyroulias, S.S. Nikolaropoulos. Pyrrolo[2,3-a]carbazoles as potential CDK1 inhibitors. Synthesis, preliminary biological evaluation and binding mode through docking simulations. J. Med. Chem 51, 1048-1052 (2008).
4. Putative bioactive conformations of amide linked cyclic myelin basic protein peptide analogues associated with experimental autoimmune encephalomyelitis
4. Z. Spyranti, G.A. Dalkas, G.A. Spyroulias, E.D. Matzourani, T. Mavromoustakos, I Friligou, T. Tselios. Putative bioactive conformations of amide linked cyclic myelin basic protein peptide analogues associated with experimental autoimmune encephalomyelitis. J. Med. Chem 50, 6039-6047 (2007). 10.1021/jm070770m
3. Simulated Interactions between Angiotensin-Converting Enzyme and Substrate Gonadotropin-Releasing Hormone: Novel Insights into Domain-Selectivity
3. A. Papakyriakou, G.A. Spyroulias, E. Sturrock, E. Manessi-Zoupa, P. Cordopatis. Simulated Interactions between Angiotensin-Converting Enzyme and Substrate Gonadotropin-Releasing Hormone: Novel Insights into Domain-Selectivity. Biochemistry ACS 46, 8753-8765 (2007).
2. Mapping protein-protein interaction by 13C-detected heteronuclear NMR spectroscopy
2. I. Bertini, I.C. Felli, L. Gonelli, R. Pierattelli, Z. Spyranti, G.A. Spyroulias. Mapping protein-protein interaction by 13C-detected heteronuclear NMR spectroscopy. J. Biomol. NMR 36, 111-122 (2006).
1. The delivery of copper for thylakoid import observed by NMR
1. L. Banci, I. Bertini, S. Ciofi-Baffoni, N.G. Kandias, G.A. Spyroulias, N.J. Robinson, M. Vanarotti, X.-C. Su. The delivery of copper for thylakoid import observed by NMR. Proc. Natl Acad Sci. USA 103, 8320-8325 (2006).