Skip to main content

Research Articles

For a full list of publications and citations see Google Scholar

VIEW LIST

Group’s Publications in peer-reviewed scientific journals since 2006:

Jan 04

44. 1H, 13C and 15N Backbone and side-chain resonance assignment of human Angiogenin

44. A. Tsika, D.S. Chatzileontiadou, D. Leonidas, G.A.Spyroulias. 1H, 13C and 15N Backbone and side-chain resonance assignment of human Angiogenin. Biomol. NMR Assign. 10, 379-383 (2016). 10.1007/s12104-016-9704-9

Jan 04

43. Computational approaches in target identification and drug discovery

43. T. Katsila, G.A. Spyroulias, G.P. Patrinos, M.-T. Matsoukas. Computational approaches in target identification and drug discovery. Comput. Struct. Biotechnol. J.  14, 177-84, (2016). 10.1016/j.csbj.2016.04.004

Jan 04

42. A peptide mimetic of 5-acetylneuraminic acid-galactose binds with high avidity to siglecs and NKG2D. PLoS One 10:e0130532

42. L.L. Eggink, G.A. Spyroulias, N.G. Jones, C.V. Hanson J.Κ. Hoober. A peptide mimetic of 5-acetylneuraminic acid-galactose binds with high avidity to siglecs and NKG2D. PLoS One 10:e0130532 (2015).  10.1371/journal.pone.0130532

Jan 04

41. Evaluation of the distribution of Paclitaxel by Immunohistochemistry and Nuclear Magnetic Resonance Spectroscopy after the application of Drug-eluting balloon in porcine ureter

41. D. Liourdi, P. Kallidonis, I. Kyriazis, A. Tsamandas, D. Karnabatidis, P. Kitrou, G.A. Spyroulias, O.N. Kostopoulou, K. Marousis, D.L. Kalpaxis, D.S. Goumenos, E. Liatsikos. Evaluation of the distribution of Paclitaxel by Immunohistochemistry and Nuclear Magnetic Resonance Spectroscopy after the application of Drug-eluting balloon in porcine ureter. J. Endourol.29, 580-589 (2015). 10.1089/end.2014.0683

Jan 04

40. The fibrate gemfibrozil is an NO- and heme-independent activator of soluble guanylyl cyclase: in vitro studies. Br. J. Pharmacol

40. I. Sharina, M. Sobolevsky, A. Papakyriakou, N. Rukoyatkina, G.A. Spyroulias, S. Gambaryan, E. Martin. The fibrate gemfibrozil is an NO- and heme-independent activator of soluble guanylyl cyclase: in vitro studies. Br. J. Pharmacol. 172, 2316-2329 (2015). 10.1111/bph.13055

Jan 04

39. 1H, 13C and 15N Backbone and side-chain resonance assignment of the LAM-RRM1 N-terminal module of La protein from Dictyostelium discoideum

39. C.T. Chasapis, A. Argyriou, M. Apostolidi, P Konstantinidou, D. Bentrop, C. Stathopoulos, G.A. Spyroulias. 1H, 13C and 15N Backbone and side-chain resonance assignment of the LAM-RRM1 N-terminal module of La protein from Dictyostelium discoideum. Biomol. NMR Assign. 9, 303-307 (2015). 10.1007/s12104-015-9597-z

Jan 04

38. NMR study of non-structural proteins – Part II. 1H, 13C, 15N backbone and side-chain resonance assignment of macro domain from Venezuelan Equine Encephalitis virus (VEEV)

38. G. Makrynitsa, D. Ntonti, K. Marousis, A.C. Tsika, J. Lichière, N. Papageorgiou, B. Coutard, D. Bentrop, G.A. Spyroulias. NMR study of non-structural proteins – Part II. 1H, 13C, 15N backbone and side-chain resonance assignment of macro domain from Venezuelan Equine Encephalitis virus (VEEV). Biomol. NMR Assign. 9, 247-251 (2015). 10.1007/s12104-014-9584-9

Jan 04

37. Backbone and side chain NMR assignment, along with the secondary structure prediction of RRM2 domain of La protein from a lower eukaryote exhibiting identical structural organization with its human homolog

37. A. Argyriou, C.T. Chasapis, M. Apostolidi, P Konstantinidou, C. Stathopoulos, D. Bentrop, G.A. Spyroulias. Backbone and side chain NMR assignment, along with the secondary structure prediction of RRM2 domain of La protein from a lower eukaryote exhibiting identical structural organization with its human homolog. Biomol. NMR Assign. 9, 219-222 (2015). 10.1007/s12104-014-9578-7

Jan 04

36. NMR study of non-structural proteins – Part I. 1H, 13C, 15N backbone and side-chain resonance assignment of macro domain from Mayaro virus (MAYV)

36. S. Melekis, A.C. Tsika, C.T. Chasapis, J. Lichière, I. Margiolaki, N. Papageorgiou, B. Coutard, D. Bentrop, G.A. Spyroulias. NMR study of non-structural proteins – Part I. 1H, 13C, 15N backbone and side-chain resonance assignment of macro domain from Mayaro virus (MAYV). Biomol. NMR Assign. 9, 191-195 (2015). 10.1007/s12104-014-9572-0

Jan 04

35. NMR Conformational dynamics of an Anthrax Lethal Factor domain studied by multiple amino acid-selective labeling

35. D. Vourtsis, C.T. Chasapis, D. Bentrop, G.A. Spyroulias. NMR Conformational dynamics of an Anthrax Lethal Factor domain studied by multiple amino acid-selective labeling. BBRC 450, 335-40 (2014). 10.1016/j.bbrc.2014.05.123

Jan 04

34. 1H, 15N, 13C assignment and secondary structure determination of two domains of La protein from D. discoideum

34. M. Apostolidi, D Vourtsis, C.T. Chasapis, C. Stathopoulos, D. Bentrop, G.A. Spyroulias. 1H, 15N, 13C assignment and secondary structure determination of two domains of La protein from D. discoideum. Biomol. NMR Assign. 8, 47-51 (2014). 10.1007/s12104-012-9450-6

Jan 04

33. ZnII/pyridyloxime complexes as potential reactivators of OP-inhibited acetylcholinesterase: in vitro and docking simulation studies

33. K.F. Konidaris, G.A. Dalkas, E. Katsoulakou, G. Pairas, C.P. Raptopoulou; F.N. Lamari, G.A. Spyroulias, E. Manessi-Zoupa. ZnII/pyridyloxime complexes as potential reactivators of OP-inhibited acetylcholinesterase: in vitro and docking simulation studies. J. Inorg. Biochem. 134, 12-19 (2014). 10.1016/j.jinorgbio.2013.12.011

Jan 04

32. Insights into soluble guanylyl cyclase activation derived from improved heme-mimetics

32. M. von Wantoch Rekowski, V. Kumar, Z. Zhou,; M. Bantzi, A. Marazioti, J. Moschner, G.A. Spyroulias, F. van den Akker, A. Giannis, A. Papapetropoulos. Insights into soluble guanylyl cyclase activation derived from improved heme-mimetics. J. Med. Chem. 56, 8948–8952 (2013). 10.1021/jm400539d

Jan 04

31. Selectivity of commonly used pharmacological inhibitors for cystathionine beta synthase (CBS) and cystathionine gamma lyase (CSE)

31. A. Asimakopoulou, P. Panopoulos, C.T. Chasapis, C. Coletta, Z. Zhou, G. Cirino, A. Giannis, C. Szabo, G.A. Spyroulias, A. Papapetropoulos. Selectivity of commonly used pharmacological inhibitors for cystathionine beta synthase (CBS) and cystathionine gamma lyase (CSE). Br. J. Pharmacol. 169, 922-932, (2013).  10.1111/bph.12171

Jan 04

30. Structure-Activity Studies of lGnRH-III through rational amino acid substitution and NMR conformational studies

30. E.V. Pappa, A.A. Zompra, Z. Spyranti, Z. Diamantopoulou, F.N. Lamari, P. Katsoris, G.A. Spyroulias, P. Cordopatis. Structure-Activity Studies of lGnRH-III through rational amino acid substitution and NMR conformational studies. Biopolymers 98, 525-534 (2012). 10.1002/bip.22123

Jan 04

29. NMR Based Insights into the conformational and interaction properties of Arkadia RING-H2 E3 Ub Ligase

29. C.T. Chasapis, N.G. Kandias, V. Episkopou, D. Bentrop, G.A. Spyroulias. NMR Based Insights into the conformational and interaction properties of Arkadia RING-H2 E3 Ub Ligase. Proteins 80, 1484-1489 (2012). 10.1002/prot.24048

Jan 04

28. Unraveling the conformational plasticity of the extracellular domain of a prokaryotic nAChR homologue in solution

28. C.T. Chasapis, A. Argyriou, P.-J. Corringer, D. Bentrop, G.A. Spyroulias. Unraveling the conformational plasticity of the extracellular domain of a prokaryotic nAChR homologue in solution by NMR. Biochemistry 50, 9681-9683 (2011). 10.1021/bi201223u

Jan 04

27. A peptide corresponding to the C-terminal region of pleiotrophin inhibits angiogenesis in vivo and in vitro

27. C. Mikelis, M. Lamprou, M. Koutsioumpa, A.G. Koutsioubas, Z. Spyranti, A.A. Zompra, N. Spiliopoulos, A.A. Vradis, P. Katsoris, G.A. Spyroulias, P. Cordopatis, J. Courty, E Papadimitriou. A peptide corresponding to the C-terminal region of pleiotrophin inhibits angiogenesis in vivo and in vitro. J. Cell. Biochem. 112, 1532-1543 (2011).  10.1002/jcb.23066

Jan 04

26. Study of the Interaction between the Amyloid Beta Peptide (1-40) and Antioxidant Compounds by NMR Spectroscopy

26. P.A. Galanakis, F.N. Bazoti, J. Bergquist, K. Markides, G.A. Spyroulias, A.Tsarbopoulos. Study of the Interaction between the Amyloid Beta Peptide (1-40) and Antioxidant Compounds by NMR Spectroscopy. Biopolymers 96, 316-327 (2011).  10.1002/bip.21558

Jan 04

25. A computational investigation on the role of glycosylation in the binding of alpha1 nicotinic acetylcholine receptor with two alpha-neurotoxins

25. N. Dimitropoulos, A. Papakyriakou, G.A. Dalkas, C. Chasapis, K. Poulas, G.A. Spyroulias. A computational investigation on the role of glycosylation in the binding of alpha1 nicotinic acetylcholine receptor with two alpha-neurotoxins. Proteins: 79, 142-152, (2011). 10.1002/prot.22867

Jan 04

24. Enzymatic Stability, Solution Structure, and Antiproliferative Effect on Prostate Cancer Cells of Leuprolide and New GnRH Peptide Analogs

24. E.V. Pappa, A.A. Zompra, Z. Spyranti, Z. Diamantopoulou, G. Pairas, F.N. Lamari, P. Katsoris, G.A. Spyroulias, P. Cordopatis. Enzymatic Stability, Solution Structure, and Antiproliferative Effect on Prostate Cancer Cells of Leuprolide and New GnRH Peptide Analogs. Biopolymers 96, 260-272 (2011). 10.1002/bip.21521

Jan 04

23. Conformational Dynamics of the Anthrax Lethal Factor

23. G.A. Dalkas, C. Chasaspis, P. Gkazonis, D. Bentrop, G.A. Spyroulias. Conformational Dynamics of the Anthrax Lethal Factor  catalytic center. Biochemistry 49, 10767-10769 (2010). 10.1021/bi1017792

Jan 04

22. Zinc Binding Properties of Engineered RING Finger Domain of Arkadia E3 Ubiquitin Ligase. Bioinorg. Chem. Appl. 2010, pii: 323152 (2010)

22. C.T. Chasapis, A. Loutsidou, M.G. Orkoula, G.A. Spyroulias.  Zinc Binding Properties of Engineered RING Finger Domain of Arkadia E3 Ubiquitin Ligase. Bioinorg. Chem. Appl. 2010, pii: 323152 (2010). 10.1155/2010/323152

Jan 04

21. Synthesis and Biological Evaluation of New CRH Analogues. Bioinorg. Chem. Appl. 2010, pii: 252348 (2010)

21. S. Papazacharias, V. Magafa, N. Bernad, G. Pairas, G.A. Spyroulias, J. Martinez, P. Cordopatis. Synthesis and Biological Evaluation of New CRH Analogues. Bioinorg. Chem. Appl. 2010, pii: 252348 (2010). 10.1155/2010/252348

Jan 04

20. Purification and Biophysical Characterization of the Core Protease Domain of Anthrax Lethal Factor. BBRC 396, 643-647 (2010)

20. P. Gkazonis, G.A. Dalkas, C. Chasaspis, A. Vlamis-Gardikas, D. Bentrop, G.A. Spyroulias. Purification and Biophysical Characterization of the Core Protease Domain of Anthrax Lethal Factor. BBRC 396, 643-647 (2010). 10.1016/j.bbrc.2010.04.144

Jan 04

19. Synthetic Peptides as Catalytic Site Maquettes of Angiotensin-I Converting Enzyme Catalytic Sites. Bioinorg. Chem. Appl. 2010

19. A.S. Galanis, Z. Spyranti, G. Pairas, E. Manessi-Zoupa, G.A. Spyroulias, P. Cordopatis. Synthetic Peptides as Catalytic Site Maquettes of Angiotensin-I Converting Enzyme Catalytic Sites. Bioinorg. Chem. Appl. 2010, pii: 820476 (2010). 10.1155/2010/820476

Jan 04

18. In position seven L- and D-Tic-substituted oxytocin and deamino oxytocin. NMR study and conformational speculations. Amino Acids 39, 539-548 (2010)

18. Spyranti, M. Fragiadaki, V. Magafa, L. Borovickova, G.A. Spyroulias, P. Cordopatis, J. Slaninova. In position seven L- and D-Tic-substituted oxytocin and deamino oxytocin. NMR study and conformational speculations. Amino Acids 39, 539-548 (2010). 10.1007/s00726-009-0470-1

Jan 04

17. A Computational Approach to the Study of the Binding Mode of Dual ACE / NEP Inhibitors. J. Chem. Inf. Model.

17. N. Dimitropoulos, A. Papakyriakou, G.A. Dalkas, E.D. Sturrock, G.A. Spyroulias. A Computational Approach to the Study of the Binding Mode of Dual ACE / NEP Inhibitors. J. Chem. Inf. Model. 50, 388-396 (2010). 10.1021/ci9005047

Jan 04

16. NMR Structural Elucidation of Myelin Basic Protein epitope 83-99 implicated in Multiple Sclerosis. Amino Acids 38, 929-936 (2010)

16. Z. Spyranti, T. Tselios, G. Deraos, J. Matsoukas, G.A. Spyroulias. NMR Structural Elucidation of Myelin Basic Protein epitope 83-99 implicated in Multiple Sclerosis. Amino Acids 38, 929-936 (2010). 10.1007/s00726-009-0301-4

Jul 15

15. Study of a lipophilic captopril analogue binding to Angiotensin I Converting Enzyme

15. G.A. Dalkas, D. Marchand, J.-C. Galleyrand, J. Martinez, G.A. Spyroulias, P. Cordopatis, F.Cavelier. Study of a lipophilic captopril analogue binding to Angiotensin I Converting Enzyme. J. Pept. Sci. 16, 91-97 (2010). 10.1002/psc.1201