People

CURRENT POSITION
09/2014-today	Professor, University of Patras, Department of Pharmacy, Patras, GREECE

 

PREVIOUS POSITION(S)
11.2015 – 08.2020 12.2009 – 08.2014	Head of the Department of Pharmacy, Univ. of Patras, GREECE Associate Professor, School of Health Sciences Dep. of Pharmacy, Univ. of Patras, GREECE
08.2003 – 11.2009	Assistant Professor, School of Health Sciences Dep. of Pharmacy, Univ. of Patras, GREECE
04.2000 – 07.2003	Post-Doctoral Researcher, Marie-Curie Fellow (2000-1) & “C. Carathedory” Fellow, Dep. of Pharmacy, Univ. of Patras, GREECE
01.1997 – 03.2000	Post-Doctoral Researcher, Marie-Curie Fellow (1998-2000), Università degli Studi di Firenze & Center of Magnetic Resonance (CERM), Florence, ITALY.
09.1995 – 12.1996	Post-Doctoral Researcher, René Descartes, Paris V, Laboratoire De Chimie et Biochimie, C.N.R.S. URA 400, Paris, FRANCE
06.1995 – 07.1995	Short-term Post-Doctoral Research, Laboratoire de Chimie de Coordination, C.N.R.S, Toulouse, FRANCE.
05.1995	Short-term Post-Doctoral Research Universita degli Studi di Firenze, Firenze, ITALY
02.1992-06.1995	PhD Research on Bioinorganic Chemistry Department of Chemistry, University of Crete Heraklion, GREECE
11.1989-02.1995	Master Degree in Bioinorganic Chemistry Department of Chemistry, University of Crete Heraklion, GREECE

 

EDUCATION
1995	Ph.D. In Chemistry, Department of Chemistry, University of Crete, Heraklion, Greece
1992	M.Sc. In Chemistry, « Bioinorganic Chemistry of Coordination Compounds », Department of Chemistry, University of Crete, Heraklion, Greece
1989	B.Sc. In Chemistry, Aristotle University of Thessaloniki, Thessaloniki, Greece

 

Publications (30 Selected publications from 129 published articles)

· Large-scale recombinant production of the SARS-CoV-2 proteome for high-throughput and structural biology applications.  A. Gallo, B. Fourkiotis, A.C. Tsika, G.A.Spyroulias & COVID19-NMR consortium. Frontiers in Molecular Biosciences  8, 653148, (2021). doi: 10.3389/fmolb.2021.653148

·  Assessment of ligand binding to the SARS-CoV-2 main protease by saturation transfer difference NMR spectroscopy. A.L. Kantsadi, E. Cattermole, M.-T. Matsoukas, G.A. Spyroulias, I. Vakonakis. Journal of Biomolecular NMR, 75, 167-178, (2021). doi: 10.1007/s10858-021-00365-x

·   The Heat Stability of Rhamnolipid Containing Egg-Protein Stabilised Oil-In-Water Emulsions. C. Russell, A. Zompra, G.A. Spyroulias, K. Salek, S.R.  Euston. Food Hydrocolloids 116, 106632 (2021).   doi.org/10.1016/j.foodhyd.2021.106632

·  Effect of dapagliflozin on urine metabolome in patients with type 2 diabetes. E. Bletsa, S. Filippas-Dekouan, C. Kostara, P. Ntafopoulos, A. Dimou, S. Chasapi, G.A. Spyroulias, M. Elisaf, E. Bairaktari, E. Ferrannini, V. Tsimihodimos. J. Clin. Endocrinol. Metab. 106, 1269-1283 (2021).  doi: 10.1210/clinem/dgab086

·  3D cell metabolomics deciphers the anti-angiogenic properties of the radioprotectant amifostine. T. Katsila, S.A. Chasapi, J.C. Gomez Tamayo, C. Chalikiopoulou, E. Siapi, G. Moros, P. Zoumpoulakis, G.A Spyroulias, D. Kardamakis. Cancers, 13, 2877, (2021).

·  Identification of compounds that bind the centriolar protein SAS-6 and inhibit its oligomerisation. J.M.C. Busch, M.-T. Matsoukas, M. Musgaard, G.A. Spyroulias, P.C. Biggin, I. Vakonakis. J. Biol. Chem. 295, 17922-17934, (2020). doi: 10.1074/jbc.RA120.014780

·   ¹H, ¹³C, and ¹⁵N backbone chemical shift assignments of the apo and the ADP-ribose bound forms of the macrodomain of SARS-CoV-2 non-structural protein 3b. F. Cantini, L. Banci, N. Altincekic, J.K. Bains, K. Dhamotharan, C. Fuks, B. Fürtig, S.L. Gande, B. Hargittay, M. Hengesbach, M.T. Hutchison, S.M. Korn, N. Kubatova, F. Kutz, V. Linhard, F. Löhr, N. Meiser, D.J. Pyper, N.S. Qureshi, C. Richter, K. Saxena, A. Schlundt, H. Schwalbe, S. Sreeramulu, J.N. Tants, A. Wacker, J.E. Weigand, J. Wöhnert, A.C. Tsika, N. Fourkiotis, G.A. Spyroulias. Biomol. NMR Assign  14, 339-346 (2020).

·  Metabolic changes in early neonatal life: NMR analysis of the neonatal metabolic profile to monitor postnatal metabolic adaptations. I. Georgakopoulou, S.A. Chasapi, S.E. Bariamis, A. Varvarigou, M. Spraul, G.A. Spyroulias. Metabolomics  16, 58 (1-12), (2020).     

·  Deciphering the nucleotide and RNA binding selectivity of the Mayaro virus macro domain. A. Tsika, S. Melekis, S.-A. Tsatsouli, N. Papageorgiou, M.J. Maté, B. Canard, B. Coutard, D. Bentrop, G.A. Spyroulias. J Mol Biol 431, 2282-2296, (2019). DOI: 10.1016/j.jmb.2019.04.013, https://doi.org/10.1016/j.jmb.2019.04.013

·  Functional and structural aspects of La overexpression in lung cancer. E. Kaliatsi, A. Argyriou, G. Bouras, M. Apostolidi, P. Konstantinidou, A.-N. Sokat, G.A. Spyroulias, C. Stathopoulos. J. Mol. Biol. 432, 166712 (2020).  

·  Conformational plasticity of the VEEV macro domain is important for binding of ADP-ribose. G. Makrynitsa, D Ntonti, K. Marousis, M. Birkou, M-T. Matsoukas, S. Asami, D. Bentrop, N. Papageorgiou B. Canard, B. Coutard,  G.A.Spyroulias. J Struct Biol. 206, 119-127. (2019). DOI: 10.1016/j.jsb.2019.02.008,  https://doi.org/10.1016/j.jsb.2019.02.008

·  Therapeutic Targeting of the Soluble Guanylate Cyclase. G. Makrynitsa, A. Argyriou, A. Zompra, G.A.Spyroulias, S. Topouzis. Curr. Med. Chem., 26, 2730-2747, (2019).  DOI: 10.2174/0929867326666190108095851, https://doi.org/10.2174/0929867326666190108095851

·  A residue-specific insight into the Arkadia E3 ubiquitin ligase activity and conformational plasticity. M Birkou, A Loutsidou, CT Chasapis, D Bentrop, M Leli, T Herrmann, V Episkopou, G.A. Spyroulias. J Mol Biol 429, 2373-2386 (2017). DOI: 10.1016/j.jmb.2017.06.012, https://doi.org/10.1016/j.jmb.2017.06.012

·  The fibrate gemfibrozil is an NO- and heme-independent activator of soluble guanylyl cyclase: in vitro studies. I Sharina, M Sobolevsky, A Papakyriakou, N Rukoyatkina, GA Spyroulias, S Gambaryan, E Martin. Br J Pharmacol 172, 2316-2329 (2015). DOI: 10.1111/bph.13055,  https://doi.org/10.1111/bph.13055

·  Insights into soluble guanylyl cyclase activation derived from improved heme-mimetics. M von Wantoch Rekowski, V Kumar, Z Zhou, M Bantzi, A Marazioti, J Moschner, GA Spyroulias, F van den Akker, A Giannis, A Papapetropoulos. J Med Chem 56, 8948–8952 (2013). DOI: 10.1021/jm400539d,  https://doi.org/10.1021/jm400539d

·  NMR Based Insights into the conformational and interaction properties of Arkadia RING-H2 E3 Ub Ligase. CT Chasapis, NG Kandias, V Episkopou, D Bentrop, GA Spyroulias.  Proteins 80, 1484-1489 (2012). DOI: 10.1002/prot.24048, https://doi.org/10.1002/prot.24048

·  Unraveling the conformational plasticity of the extracellular domain of a prokaryotic nAChR homologue in solution by NMR. CT Chasapis, A Argyriou, P-J Corringer, D Bentrop, GA Spyroulias. Biochemistry 50, 9681-9683 (2011). DOI: 10.1021/bi201223u,  https://doi.org/10.1021/bi201223u

·  The NMR Conformational Dynamics of the Anthrax Lethal Factor (LF) catalytic center. GA Dalkas, C Chasaspis, P Gkazonis, D Bentrop, GA Spyroulias.  Biochemistry 49, 10767-10769 (2010). DOI: 10.1021/bi1017792, https://doi.org/10.1021/bi1017792,

·  Purification and Biophysical Characterization of the Core Protease Domain of Anthrax Lethal Factor. P Gkazonis, GA Dalkas, C Chasaspis, A Vlamis-Gardikas, D Bentrop, GA Spyroulias. BBRC 396, 643-647 (2010). DOI: 10.1016/j.bbrc.2010.04.144, https://doi.org/10.1016/j.bbrc.2010.04.144

·  High yield expression, and NMR characterization of Arkadia E3 Ubiquitin Ligase RING-H2 finger domain. NG Kandias, CT Chasapis, V Episkopou, D Bentrop, GA Spyroulias BBRC 378, 498-502 (2009). DOI: 10.1016/j.bbrc.2008.11.055,  https://doi.org/10.1016/j.bbrc.2008.11.055

·  Mechanism of CuA assembly. LA Abriata, L Banci, I Bertini, S Ciofi-Baffoni, P Gkazonis, GA Spyroulias, AJ Vila, S Wang. Nature Chemical Biology 4, 599-601 (2008). DOI: 10.1038/nchembio.110, https://dx.doi.org/10.1038%2Fnchembio.110

·  Soluble guanylyl cyclase (sGC) activation by HMR-1766 (ataciguat) in cells exposed to oxidative stress. Z Zhou, A Pyriochou, A Kotanidou, GA Dalkas, M van Eickels, GA Spyroulias, C. Roussos A. Papapetropoulos. Am J Physiol Heart Circ Physiol. 295, Η1763-1771 (2008). DOI: 10.1152/ajpheart.51.2008,  https://doi.org/10.1152/ajpheart.51.2008

· Pyrrolo[2,3-a]carbazoles as potential CDK1 inhibitors. Synthesis, preliminary biological evaluation and binding mode through docking simulations. M.A. Fousteris, A. Papakyriakou, A. Koutsourea, M. Manioudaki, E. Lampropoulou, E. Papadimitriou, G.A. Spyroulias, S.S. Nikolaropoulos. J. Med. Chem. 51, 1048-1052 (2008).   DOI: 10.1021/jm0700666, https://doi.org/10.1021/jm0700666

·  Putative bioactive conformations of amide linked cyclic myelin basic protein peptide analogues associated with experimental autoimmune encephalomyelitis.  Z. Spyranti, G.A. Dalkas, G.A. Spyroulias, E.D. Matzourani, T. Mavromoustakos, I Friligou, T. Tselios. J. Med. Chem. 50, 6039-6047 (2007). DOI: 10.1021/jm070770m  https://doi.org/10.1021/jm070770m

·  Simulated Interactions between Angiotensin-Converting Enzyme and Substrate Gonadotropin-Releasing Hormone: Novel Insights into Domain-Selectivity. A. Papakyriakou, G.A. Spyroulias, E. Sturrock, E. Manessi-Zoupa, P. Cordopatis.  Biochemistry 46, 8753-8765 (2007). DOI: 10.1021/bi700253q,  https://doi.org/10.1007/s10858-006-9068-z

·  The delivery of copper for thylakoid import observed by NMR. L. Banci, I. Bertini, S. Ciofi-Baffoni, N.G. Kandias, G.A. Spyroulias, N.J. Robinson, M. Vanarotti, X.-C. Su. Proc. Natl Acad Sci. USA 103, 8320-8325 (2006). DOI: 10.1073/pnas.0600142103, https://doi.org/10.1073/pnas.0600142103

·  The stability of the cytochrome c scaffold as revealed by NMR spectroscopy. S.J. Berners-Price, I. Bertini, H.B. Gray, G.A. Spyroulias, P. Turano. J. Inorg. Biochem. 98, 814-823 (2004). DOI: 10.1016/j.jinorgbio.2003.12.010, https://doi.org/10.1016/j.jinorgbio.2003.12.010

·  DME-substituted cytochrome b₅: Structure and Stability. L. Banci, I. Bertini, B. Bianchini, P. Hajieva, JBIC 6, 490-503 (2001). DOI: 10.1007/s007750100217, https://doi.org/10.1007/s007750100217

·  Solution Structure of reduced horse heart cytochrome c. L. Banci, I. Bertini, G. Huber, G.A. Spyroulias, P. Turano. JBIC 4, 21-31 (1999). DOI: 10.1007/s007750050285, https://doi.org/10.1007/s007750050285

·  The Conformational flexibility of Oxidized cytochrome c, studied through its interaction with NH₃ and at High Temperature.  L. Banci, I. Bertini, G.A. Spyroulias, P. Turano. Eur. J. Inorg. Chem. 583-591 (1998). DOI: 10.1021/bi963025c  https://doi.org/10.1021/bi963025c

 

Total Citations ( Google Scholar Profile: Georgios A. Spyroulias)	>2880
h-index/i10-index*	28/68
Number of submitted PDB entries (pending submissions)	29
Number of submitted BMRB (NMR data) entries (pending submissions)	34
https://scholar.google.com/citations?hl=en&user=eEwUbW0AAAAJ

CONFERENCES/WORKSHOPS/etc.
·        A total of ~100 National & International Conferences with ~300 Posters presentations ·        Invited Oral presentations (selected 25 Talks in Scientific Conferences & Invited seminars – Total: 108):

• 24/09/2020 – «The structural and dynamic basis for the function of biological molecules through solution NMR spectroscopy» Adriatic NMR Conference 2020, May 26-28, Peroj, Croatia, 2020
• 04/09/2019 – “NMR insights on the activation mechanism of a heme enzyme” Invited Lecture, Central European NMR Symposium & Bruker users meeting, University of Belgrade, Faculty of Chemistry, 04-05/09/2019, Serbia
• 25/11/2018 – “The structural and dynamic basis for the function of biological molecules through solution NMR spectroscopy”, Invited Lecture, 69th Conference of the Hellenic Society of Biochemistry & Molecular Biology 23-25/11/2018, Larissa, Greece
• 30/05/2018 – «Gas-inflow triggered stimulation of a heme enzyme monitored by NMR», EMBO Workshop – Challenges for magnetic resonance in life sciences, 27-31/05/2018, Grosseto, Italy.
• 02/10/2017 – “Gas sensing in a heme protein monitored through NMR”, 2^nd COST “FesBioNet” Meeting, Trest 1-4/10/2017, Czech Republic
• 26/06/2017 – “NMR studies of RNA and ADP-ribose binding proteins”, Invited by Prof. Michael Sattler, Chair for Biomolecular NMR Spectroscopy, Technical University of Munich, STB Institute of Structural Biology, Bavarian NMR Center (BNMRZ), Munich, Germany
• 05/05/2017 – “NMR Approaches in Structural Biology & Drug Design”, Meeting on “Biochemistry & Health: From the cell to the therapy”, University of Thessaly, Larissa, Greece.
• 27/04/2017 – “Targeting the architecture, the plasticity and the socialization determinants of biomolecules with pharmaceutical interest by NMR”, Invited by Prof. Steve Euston, Heriot-Watt University, Edinburgh, UK.
• 03/12/2016 – “NMR in Chemistry, Biology, Drug Design & Diagnostics”, 22^nd PanHellenic Conference of Chemistry, 2-4/12/2016, Thessaloniki, GREECE.
• 23/06/2016 – «NMR insights into the Conformational Dynamics and interaction of biomolecules with therapeutic interest», Invited Lecture, 2^nd International Conference of Controlled Release Society, Athens, GREECE
• 08/06/2016 – « NMR conformational dynamics & RNA recognition properties of La protein domains La, RRM1 and RRM2», Chianti Workshop 2016, 5-10/06/2016, Grosetto, Italy
• 21/04/2016 – «NMR Insights on the conformational plasticity and interaction of biomolecules», REGPOT-InnovCrete Seminars, FORTH-IMBB, University of Crete, Heraklion, Crete, Greece
• 13/02/2015 – «Conformation, Plasticity and Socialization of biomolecules through NMR » invited by Dr. Iro Georgoussi, NCSR Demokritos, Institute of Biosciences & Applications, Athens, GREECE
• 21/09/2014 – «NMR Conformational Dynamics of La and RRM1 Motifs of La Protein», CTSB & HeCrA7, FORTH-IMBB, Heraklion Crete,
• 20/05/2014 – «Insights on the conformational plasticity of drug-target proteins» 32^nd Cyprus – Noordwijkerhout – Camerino Symposium – Trends in Drug Research, 18-23/05/2014, Limassol, CYPRUS.
• 06/04/2014 – «Structural Biology by NMR:  Knowledge transfer form EU RIs to Greece», ICRI-2014 – Strategic pipeline planning: from sample preparation to 3D structure determination with bio SAXS and other biophysical techniques, National Hellenic Research Foundation, Athens, GREECE.
• 08/12/2012 – «Solution NMR Studies of E3 Ub Ligase RING and Alphaviruses MACRO Domains», Turkish NMR Meeting, 07-09/12/2012, Istanbul, TURKEY.
• 15/11/2012 – «NMR Structural Biology at University of Patras & the SEEDRUG Project », 3rd EAST-NMR Anual User Meeting, 13-16/11/2012, Lasko, SLOVENIA
• 04/09/2012 – «Selective amino acid isotope labeling strategies for solution NMR studies of high-molecular-weight protein drug-targets» 32^nd European Peptide Symposium, 04/09/2012, Athens, GREECE.
• 04/06/2012 – «The SEE DRUG Project at University of Patras» WIRE2012 – Week of Innovative Regions in Europe, Invited by the WIRE2012 Organizing Committee & REGPOT Program Officer, 03-05/06/2012, Krakow, POLLAND.
• 26/05/2012 – «Identifying functionally important residues of Arkadia E3 Ubiquitin Ligase RING Domain in E2 Recruitment and E3-E2 Interaction » 15th Symposium on Medicinal Chemistry, 25-27/05/2012, Athens, GREECE
• 17/04/2012 – «NMR study of Arkadia E3 ubiquitin ligase domain to correlate Zn(II) coordination with protein architecture, dynamics and function» 12^th EURASIA Conference in Chemical Sciences, 17-21/04/2012, Corfu GREECE.
• 02/11/2010 – « NMR insights into the conformational dynamics of native and engineered forms of Arkadia E3 Ubiquitin ligase C-terminal Domain» “NMR in Life Sciences” – 3^rd International Symposium on Organic Chemistry, 30/10-02/11/2010, Sofia, BULGARY.
• 01/10/2010 – «NMR-Based Residue Specific Insights into the Structure-Function Correlation of Arkadia E3 Ubiquitin Ligase Ring Finger Domain» EAST-NMR 1st Young Investigators Meeting, 29/09-01/10/2010, Istanbul, TURKEY.
• 24/09/2010 – «Structure-Activity Relationship of Arkadia Ring finger E3 ubiquitin ligase through NMR spectroscopy» 18^th Euro QSAR, 19-24/09/2010, Rhodes, GREECE.

 

MEMBERSΗIPS & reviewing activities
2003 – today	Reviewer in Scientific journals:  Biochemistry, Chemical Reviews, Journal οf Medicinal Chemistry, Journal οf Chemical Information & Modeling (American Chemical Society); Journal of Molecular Biology, Spectrochimica Acta: Molecular & Biomolecular Spectroscopy, Journal of Molecular Graphics & Modeling, Polyhedron (Elsevier); Biotechnology Journal, Journal of Peptide Science (Wiley InterScience); BMC Biochemistry, BMC Biotechnology (BioMed Central); PLoS ONE (Public Library of Science); FEBS Journal, Acta Biochimica et Biophysica Sinica   (Blackwell Publishing); Current Pharmaceutical Design, Current Enzyme Inhibition (Bentham Science Publishers); Bioinorganic Chemistry Applications (Hindawi); Journal of Molecular Modeling, Molecular Biology Reports (Springer); Molecular Simulation (Taylor & Francis) Reviewer in Funding agencies:  Medical Research Council & Welcome Trust (UK), INSTRUCT (EU/H2020) IKY, GSRT & ELIDEK, University of Thessaly/Larissa, NCSR Demokritos/Athens (GR)
1995 – today	Memberships: Greek Chemists Association, Marie-Curie Fellowship Association (Hellenic MCFA, Vice-Chair, 2006- 2008), European Peptide Society (Greek Effective Member in EPS, 2014- ), Ampere Committee Member (2016-  ), Hellenic Society for Biochemistry & Molecular Biology, Hellenic Society for Computational Biology and Bioinformatics, Hellenic Crystallographic Association

 

Teaching activities
2003 – today	Teaching position – “Design/Simulation of Bioactive molecules with Pharmaceutical Interest”, Biochemistry, NMR Spectroscopy topic in Instrumental Analysis & Spectroscopy, General Chemistry, (bio)Informatics

 

SUPERVISION OF GRADUATE STUDENTS and POSTDOCTORAL FELLOWS
2003 – today	7 Post-docs/7 PhDs (completed) & 6 On-going/38 Master Students (completed) & 4 Οn-going University of Patras, Department of Pharmacy, GREECE

FELLOWSHIPS and AWARDS
11.1989 -10.1994	« EMY » Fellowship for PhD research, Ministry of Education, Univ. of Crete, GREECE;
1993	« DIGITAL CORPORATION AWARD » for Achievement in PhD Research, Univ of Crete, GREECE
11.1996 – 12.1996	« CLAUDE BERNARD Fondation » Grant (U René Descartes, Paris, FRANCE ;).
11.1997 – 12.1999	« Marie-Curie Post-Doctoral Research Training Grant», Center of Magnetic Resonance (CERM), Univ. of Florence, ITALY
05.2000 – 04.2001	« Marie-Curie Return Grant», School of Health Sciences, Dept of Pharmacy, Univ of Patras, GREECE
11.2001 – 08.2003	« C. Caratheodory Post-Doctoral Grant», Dept of Pharmacy, Univ of Patras, GREECE
05.2003 – 08.2003	ΕΜΒΟ Short-term Research Grant, Center of Magnetic Resonance (CERM), Univ. of Florence, ITALY
05.2004 – 08.2004	ΕΜΒΟ Short-term Research Grant, Center of Magnetic Resonance (CERM), Univ. of Florence, ITALY

Research Grants (Total Budget > 8.00 M€)
Project Title	Funding source	Period	Role of the PI
Marie Curie Research Training Grant, “NMR Spectroscopy to study the factors controlling the folding/unfolding process in Paramagnetic Metalloproteins”	EU-FP6, Contract No : ERBFMBICT 972477.	1997-1999	Grant Holder
Marie Curie Return Grant, “NMR Structural Studies of Chemically Modified c-Cytochromes as a probe of Protein Folding Pathways”	EU-FP6, Contract No : HPMF-CT-1999-00344.	2000-2001	Grant Holder
INNO-FARM – Joint Research & Technological development Program of West Greece”	GSRT, Ministry of Development, GREECE	2006-2008	Co-Investigator
FP7-HEALTH-2007-2.1.1-5. “NEUROCYPRES: Neurotrasmitter Cys-loop receptors: structure, function and disease (NeuroCypress)”	EU-FP7, HEALTH-F4-2008-202088	2008-2012	Principal Investigator, UPAT’s Team Leader
FP7-INFRA-2008-1.1.1., “EAST-NMR: Enhancing Access and Services To East European users towards an efficient and coordinated pan-European pool of NMR capacities to enable global collaborative research and boost technological advancements”	EU-FP7, Research Infrastructures, CP-CSA-Infra-228461	2009-2013	Principal Investigator, UPAT’s Team Leader
HERACLITUS ΙΙ: “Expression, Characterization and Structural Investigation through Nuclear Magnetic Resonance (NMR) of the Bacillus anthracis Anthrax Lethal Factor Zn-protease Catalytic Site”	Greek Ministry of Education, GREECE	2011-2014.	Principal Investigator
GSRT- THALIS: “Hydrogen sulfide, a new endogenous regulator of angiogenesis: signaling, physiology/pathophysiology and development of pharmacological inhibitors”	GSRT & Greek Ministry of Education, GREECE	2011-2015	Co-Investigator
FP7-REGPOT-2011-1. SEE-DRUG: Establishment of Centre of Excellence for Structure-Based Drug Target Characterization: Strengthening the Research Capacity of South-Eastern Europe	EU-FP7, Capacities – Research Potential, CT-2011-285950	2012-2015.	Coordinator
National Greek Roadmap of Research Infrastructures (RIs) – RI: “INSPIRED”	GSRT & Ministry of Development, GREECE	2018-2021	Coordinator of UPAT’s Project (“UPAT-RISF”)
National Greek Roadmap of Research Infrastructures (RIs) – RI: “OMIC-ENGINE”	GSRT & Ministry of Development, GREECE	2017-2021	Principal Investigator, UPAT’s Team Leader
H2020-BG-2014-2, BG-03-2014 – “MARISURF: Novel, Sustainable marine Bio-surfactant/Bio-emulsifiers for commercial exploitation	EU-H2020, No 635340	2015-2020	Principal Investigator, UPAT’s Team Leader
H2020 – H2020-INFRAIA-2014-2015 – “iNEXT: Infrastructure for NMR, EM and X-ray crystallography for translational research”,	EU-H2020, No 653706	2015-2020	Principal Investigator, UPAT’s Team Leader
NSRF 2014-2020, “The impact of the catalytic region of the E3 ubiquitin ligase Arkadia in function and diagnosis”	GSRT & Ministry of Development, GREECE	2017-2019	Principal Incvestigator
H2020-MSCA-IF-2017 – “NMRSIGN: NMR insights on the soluble Guanylyl Cyclase conformational dynamics to illuminate the SIGNaling pathway”	EU-H2020, MARIE SKŁODOWSKA-CURIE ACTIONS	2018-2020	Co-Supervisor & PI of the Coordinating Organization
RESEARCH–CREATE-INNOVATE, MIS 5067545, – “POLYPEPPHARM: Improved generic polypeptide drugs with innovative pharmaceutical forms – Τ2ΕΔΚ-00996”	GSRT & Ministry of Development, GREECE	2020-2023	Co-Investigator