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G.A. Spyroulias

Personal Information

Date of birth: 16th October 1965

Place of Residence: Patra

E-mail: G.A.Spyroulias@upatras.gr

Tel.: +30 2610 962 350

Full CV
CURRENT POSITION(S)
09/2014-today Professor, University of Patras, Department of Pharmacy, Patras, GREECE
PREVIOUS POSITION(S)
11.2015 – 08.2020

12.2009 – 08.2014

 Head of the Department of Pharmacy, Univ. of Patras, GREECE

Associate Professor, School of Health Sciences Dep. of Pharmacy, Univ. of Patras, GREECE
08.2003 – 11.2009 Assistant Professor, School of Health Sciences Dep. of Pharmacy, Univ. of Patras, GREECE
04.2000 – 07.2003 Post-Doctoral Researcher, Marie-Curie Fellow (2000-1) & “C. Carathedory” Fellow, Dep. of Pharmacy, Univ. of Patras, GREECE
01.1997 – 03.2000 Post-Doctoral Researcher, Marie-Curie Fellow (1998-2000), Università degli Studi di Firenze & Center of Magnetic Resonance (CERM), Florence, ITALY.
09.1995 – 12.1996 Post-Doctoral Researcher, René Descartes, Paris V, Laboratoire De Chimie et Biochimie, C.N.R.S. URA 400, Paris, FRANCE
06.1995 – 07.1995 Short-term Post-Doctoral Research, Laboratoire de Chimie de Coordination, C.N.R.S, Toulouse, FRANCE.
05.1995 Short-term Post-Doctoral Research Universita degli Studi di Firenze, Firenze, ITALY
02.1992-06.1995 PhD Research on Bioinorganic Chemistry Department of Chemistry, University of Crete Heraklion, GREECE
11.1989-02.1995 Master Degree in Bioinorganic Chemistry Department of Chemistry, University of Crete Heraklion, GREECE
EDUCATION
1995 Ph.D. In Chemistry, Department of Chemistry, University of Crete, Heraklion, Greece
1992 M.Sc. In Chemistry, « Bioinorganic Chemistry of Coordination Compounds », Department of Chemistry, University of Crete, Heraklion, Greece
1989 B.Sc. In Chemistry, Aristotle University of Thessaloniki, Thessaloniki, Greece
·        Structure-based rational design of an efficient SARS-CoV-2 Nsp3 macro domain hydrolase inhibitor.  R. Krishnathas, K. Mineev, N.K. Fourkiotis, Ch. Sideras-Bisdekis, A.C. Tsika, S. Lakshmi Gande, V. Linhard, S. Sreeramulu, F. Lennartz, M.S. Weiss, G.A. Spyroulias, H. Schwalbe.  ACS Chemical Biology. Submitted,  (2025).

·        Unveiling the Metabolomic Profile of Growth Hormone Deficiency Children Using NMR Spectroscopy.  E.A. Aggelaki, A. Giannakopoulos, P.D. Georgiopoulou, S.A. Chasapi, A. Efthymiadou, D. Kritikou, D. Chrysis, G.A. Spyroulias.  Metabolites 21, 25 (2025). https://doi.org/10.1007/s11306-024-02217-9

·        Identification of small-molecule antagonists targeting the Growth Hormone Releasing Hormone Receptor (GHRHR).  M.-T. Matsoukas, T. Radomsky, V. Panagiotopoulos, R. du Preez, M. Papadourakis, K. Tsianakas, R. Millar, R. Anderson, G.A. Spyroulias, C. Newton.  J. Chem. Inf. Model. 64, 7056-7067, (2024). https://pubs.acs.org/doi/10.1021/acs.jcim.4c00577

·        Comprehensive fragment screening of the SARS-CoV-2 proteome explores novel chemical space for drug development.  COVID19-NMR Consortium, and Α.C. Tsika, N.K. Fourkiotis, A. Gallo, G.A. Spyroulias.   Angewandte Chemie Int Ed Engl 61, e202205858 (2022). https://doi.org/10.1002/anie.202205858

·        Binding adaption of GS-441524 diversifies macro domains and downregulate SARS-CoV-2  de-MARylation capacity.  Α.C. Tsika, A. Gallo, N.K. Fourkiotis, A.I. Argyriou, S. Sreeramulu, F. Löhr, V.V. Rogov, C. Richter, V. Linhard, S.L. Gande, N. Altincekic, R. Krishnathas, I. Elamri, H. Schwalbe, J. Wollenhaupt, M.S. Weiss, G.A. Spyroulias. J. Mol. Biol. 434, 167720 (2022). https://doi.org/10.1016/j.jmb.2022.167720

·        Structural perspectives on sGC stimulators’ binding to H-NOX domain regulated by the redox state of the heme.  G. I. Makrynitsa, A.I. Argyriou, A. Zompra, K. Salagiannis, V. Vazoura, A. Papapetropoulos, S.Topouzis, G.A. Spyroulias.  Front. Cell Develop. Biol., 10, 925457, (2022).  https://doi.org/10.3389/fcell.2022.925457

·        Large-scale recombinant production of the SARS-CoV-2 proteome for high-throughput and structural biology applications.  A. Gallo, B. Fourkiotis, A.C. Tsika, G.A.Spyroulias & COVID19-NMR consortium. Frontiers in Molecular Biosciences  8, 653148, (2021). doi: 10.3389/fmolb.2021.653148

·        Assessment of ligand binding to the SARS-CoV-2 main protease by saturation transfer difference NMR spectroscopy. A.L. Kantsadi, E. Cattermole, M.-T. Matsoukas, G.A. Spyroulias, I. Vakonakis. Journal of Biomolecular NMR, 75, 167-178, (2021). doi: 10.1007/s10858-021-00365-x

·        Effect of dapagliflozin on urine metabolome in patients with type 2 diabetes. E. Bletsa, S. Filippas-Dekouan, C. Kostara, P. Ntafopoulos, A. Dimou, S. Chasapi, G.A. Spyroulias, M. Elisaf, E. Bairaktari, E. Ferrannini, V. Tsimihodimos. J. Clin. Endocrinol. Metab. 106, 1269-1283 (2021).  doi: 10.1210/clinem/dgab086

·        1H, 13C, and 15N backbone chemical shift assignments of the apo and the ADP-ribose bound forms of the macrodomain of SARS-CoV-2 non-structural protein 3b. F. Cantini, L. Banci, N. Altincekic, J.K. Bains, K. Dhamotharan, C. Fuks, B. Fürtig, S.L. Gande, B. Hargittay, M. Hengesbach, M.T. Hutchison, S.M. Korn, N. Kubatova, F. Kutz, V. Linhard, F. Löhr, N. Meiser, D.J. Pyper, N.S. Qureshi, C. Richter, K. Saxena, A. Schlundt, H. Schwalbe, S. Sreeramulu, J.N. Tants, A. Wacker, J.E. Weigand, J. Wöhnert, A.C. Tsika, N. Fourkiotis, G.A. Spyroulias. Biomol. NMR Assign  14, 339-346 (2020).

·        Metabolic changes in early neonatal life: NMR analysis of the neonatal metabolic profile to monitor postnatal metabolic adaptations. I. Georgakopoulou, S.A. Chasapi, S.E. Bariamis, A. Varvarigou, M. Spraul, G.A. Spyroulias. Metabolomics  16, 58 (1-12), (2020).     

·        Deciphering the nucleotide and RNA binding selectivity of the Mayaro virus macro domain. A. Tsika, S. Melekis, S.-A. Tsatsouli, N. Papageorgiou, M.J. Maté, B. Canard, B. Coutard, D. Bentrop, G.A. Spyroulias. J Mol Biol 431, 2282-2296, (2019). DOI: 10.1016/j.jmb.2019.04.013, https://doi.org/10.1016/j.jmb.2019.04.013

·        Functional and structural aspects of La overexpression in lung cancer. E. Kaliatsi, A. Argyriou, G. Bouras, M. Apostolidi, P. Konstantinidou, A.-N. Sokat, G.A. Spyroulias, C. Stathopoulos. J. Mol. Biol. 432, 166712 (2020).  

·        A residue-specific insight into the Arkadia E3 ubiquitin ligase activity and conformational plasticity. M Birkou, A Loutsidou, CT Chasapis, D Bentrop, M Leli, T Herrmann, V Episkopou, G.A. Spyroulias. J Mol Biol 429, 2373-2386 (2017). DOI: 10.1016/j.jmb.2017.06.012, https://doi.org/10.1016/j.jmb.2017.06.012

·        Insights into soluble guanylyl cyclase activation derived from improved heme-mimetics. M von Wantoch Rekowski, V Kumar, Z Zhou, M Bantzi, A Marazioti, J Moschner, GA Spyroulias, F van den Akker, A Giannis, A Papapetropoulos. J Med Chem 56, 8948–8952 (2013). DOI: 10.1021/jm400539d,  https://doi.org/10.1021/jm400539d

·        Mechanism of CuA assembly. LA Abriata, L Banci, I Bertini, S Ciofi-Baffoni, P Gkazonis, GA Spyroulias, AJ Vila, S Wang. Nature Chemical Biology 4, 599-601 (2008). DOI: 10.1038/nchembio.110, https://dx.doi.org/10.1038%2Fnchembio.110

·        Pyrrolo[2,3-a]carbazoles as potential CDK1 inhibitors. Synthesis, preliminary biological evaluation and binding mode through docking simulations. M.A. Fousteris, A. Papakyriakou, A. Koutsourea, M. Manioudaki, E. Lampropoulou, E. Papadimitriou, G.A. Spyroulias, S.S. Nikolaropoulos. J. Med. Chem. 51, 1048-1052 (2008).   DOI: 10.1021/jm0700666, https://doi.org/10.1021/jm0700666

·        Putative bioactive conformations of amide linked cyclic myelin basic protein peptide analogues associated with experimental autoimmune encephalomyelitis.  Z. Spyranti, G.A. Dalkas, G.A. Spyroulias, E.D. Matzourani, T. Mavromoustakos, I Friligou, T. Tselios. J. Med. Chem. 50, 6039-6047 (2007). DOI: 10.1021/jm070770m  https://doi.org/10.1021/jm070770m

·        Simulated Interactions between Angiotensin-Converting Enzyme and Substrate Gonadotropin-Releasing Hormone: Novel Insights into Domain-Selectivity. A. Papakyriakou, G.A. Spyroulias, E. Sturrock, E. Manessi-Zoupa, P. Cordopatis.  Biochemistry 46, 8753-8765 (2007). DOI: 10.1021/bi700253q,  https://doi.org/10.1007/s10858-006-9068-z

·        The delivery of copper for thylakoid import observed by NMR. L. Banci, I. Bertini, S. Ciofi-Baffoni, N.G. Kandias, G.A. Spyroulias, N.J. Robinson, M. Vanarotti, X.-C. Su. Proc. Natl Acad Sci. USA 103, 8320-8325 (2006). DOI: 10.1073/pnas.0600142103, https://doi.org/10.1073/pnas.0600142103

·        Solution Structure of reduced horse heart cytochrome c. L. Banci, I. Bertini, G. Huber, G.A. Spyroulias, P. Turano. JBIC 4, 21-31 (1999). DOI: 10.1007/s007750050285, https://doi.org/10.1007/s007750050285

 
Total Citations ( Google Scholar Profile: Georgios A. Spyroulias) >4400
h-index/i10-index* 32/94
Number of submitted PDB entries (pending submissions) 37
Number of submitted BMRB (NMR data) entries (pending submissions) 45
 
CONFERENCES/WORKSHOPS/etc.
·      A total of >100 National & International Conferences with >300 Posters presentations

·      Invited Oral presentations (selected Talks in Scientific Conferences & Invited seminars  >130):
  • 03/07/2025 – “Integrative structural biology to study ADP-ribose binding proteins and ADP-ribose hydrolases”, 1st International Meeting on RNA & RNases, 3-4 July, 2025, Barcelona, Spain
  • 11/05/2025 – “NMR evaluation of ligand binding among protein players in the ADP­ ribosylation pathway”    FEBS Advanced Course: PARP2025: from molecular aspects to clinical applications”, 11-15 May, 2025, Illkirch, Strasbourg, FR
  • 09-11/04/2025 –“NMR evaluation of ligand binding among protein players in the ADP-ribosylation pathway”, European Conference on Allostery in Drug Discovery, 9-11 April, 2025, BRFAA, Athens, Greece
  • 08/04/2024 – “NMR investigation of protein “players” in the ADP-ribosylation pathway”, The Netherland Cancer Institute, Invited by Anastassis Perrakis, April 08, 2024, Amsterdam, THE NETHERLANDS.
  • 01/02/2024 – “NMR investigation of protein “players” in the ADP-ribosylation pathway”, Goethe University of Frankfurt, BMRZ Center, Invited by Harald Schwalbe, February 01, 2024, Frankfurt, GERMANY
  • 26/09/2024 – “NMR investigation of protein “players” in the ADP-ribosylation pathway”, 29th Panhellenic Chemistry Conference, September 25-28, 2024, National Kapodistrian University of Athens, GREECE.
  • 22/10/2023 – “NMR investigation of human and viral protein homologues implicated in immune response”, 11th HECRA Conference, October 22, 2023, Larissa, Greece
  • 13/06/2023 – “NMR monitoring of heme enzyme’s functional dynamics and their role in the activation mechanism”, 16th ISABC (International Symposium in Applied Bioinorganic Chemistry), 11-14 June, 2023, Ioannina, Greece
  • “NMR Structural biology of SARS-CoV-2 nsP3 proteins; new targets for viral replication inhibition”. Chianti Workshop 2022, June 18-24, 2022, Grosetto, Italy.
  • 21/10/2022 – “Exploiting NMR conformational and functional dynamics in drug design efforts”. CAPSTONE Workshop, National Kapodistrian University of Athens, Department of Biology, Athens, Greece
  • 25/02/2021 – “NMR Structural biology of SARS-CoV-2 nsP3 proteins; new targets for viral replication inhibition”, 18th Hellenic Symposium on Medicinal Chemistry, Virtual Symposium, 25-27 February, 2021
  • 24/09/2020 – «The structural and dynamic basis for the function of biological molecules through solution NMR spectroscopy» Adriatic NMR Conference 2020, May 26-28, Peroj, Croatia, 2020
  • 04/09/2019 – “NMR insights on the activation mechanism of a heme enzyme” Invited Lecture, Central European NMR Symposium & Bruker users meeting, University of Belgrade, Faculty of Chemistry, 04-05/09/2019, Serbia
  • 25/11/2018 – “The structural and dynamic basis for the function of biological molecules through solution NMR spectroscopy”, Invited Lecture, 69th Conference of the Hellenic Society of Biochemistry & Molecular Biology 23-25/11/2018, Larissa, Greece
  • 30/05/2018 – «Gas-inflow triggered stimulation of a heme enzyme monitored by NMR», EMBO Workshop – Challenges for magnetic resonance in life sciences, 27-31/05/2018, Grosseto, Italy.
  • 02/10/2017 – “Gas sensing in a heme protein monitored through NMR”, 2nd COST “FesBioNet” Meeting, Trest 1-4/10/2017, Czech Republic
  • 26/06/2017 – “NMR studies of RNA and ADP-ribose binding proteins”, Invited by Prof. Michael Sattler, Chair for Biomolecular NMR Spectroscopy, Technical University of Munich, STB Institute of Structural Biology, Bavarian NMR Center (BNMRZ), Munich, Germany
  • 27/04/2017 – “Targeting the architecture, the plasticity and the socialization determinants of biomolecules with pharmaceutical interest by NMR”, Invited by Prof. Steve Euston, Heriot-Watt University, Edinburgh, UK.
  • 08/06/2016 – « NMR conformational dynamics & RNA recognition properties of La protein domains La, RRM1 and RRM2», Chianti Workshop 2016, 5-10/06/2016, Grosetto, Italy
  • 21/04/2016 – «NMR Insights on the conformational plasticity and interaction of biomolecules», REGPOT-InnovCrete Seminars, FORTH-IMBB, University of Crete, Heraklion, Crete, Greece
  • 21/09/2014 – «NMR Conformational Dynamics of La and RRM1 Motifs of La Protein», CTSB & HeCrA7, FORTH-IMBB, Heraklion Crete,
  • 08/12/2012 – «Solution NMR Studies of E3 Ub Ligase RING and Alphaviruses MACRO Domains», Turkish NMR Meeting, 07-09/12/2012, Istanbul, TURKEY.
  • 15/11/2012 – «NMR Structural Biology at University of Patras & the SEEDRUG Project », 3rd EAST-NMR Anual User Meeting, 13-16/11/2012, Lasko, SLOVENIA
  • 04/09/2012 – «Selective amino acid isotope labeling strategies for solution NMR studies of high-molecular-weight protein drug-targets» 32nd European Peptide Symposium, 04/09/2012, Athens, GREECE.
  • 04/06/2012 – «The SEE DRUG Project at University of Patras» WIRE2012 – Week of Innovative Regions in Europe, Invited by the WIRE2012 Organizing Committee & REGPOT Program Officer, 03-05/06/2012, Krakow, POLLAND.

 

MEMBERSΗIPS & reviewing activities
2003 – today Reviewer in Scientific journals:  Biochemistry, Chemical Reviews, Journal οf Medicinal Chemistry, Journal οf Chemical Information & Modeling (American Chemical Society); Journal of Molecular Biology, Spectrochimica Acta: Molecular & Biomolecular Spectroscopy, Journal of Molecular Graphics & Modeling, Polyhedron (Elsevier); Biotechnology Journal, Journal of Peptide Science (Wiley InterScience); BMC Biochemistry, BMC Biotechnology (BioMed Central); PLoS ONE (Public Library of Science); FEBS Journal, Acta Biochimica et Biophysica Sinica  (Blackwell Publishing); Current Pharmaceutical Design, Current Enzyme Inhibition (Bentham Science Publishers); Bioinorganic Chemistry Applications (Hindawi); Journal of Molecular Modeling, Molecular Biology Reports (Springer); Molecular Simulation (Taylor & Francis)

Reviewer in Funding agencies:  Medical Research Council & Welcome Trust (UK), INSTRUCT (EU/H2020) IKY, GSRT & ELIDEK, University of Thessaly/Larissa, NCSR Demokritos/Athens (GR)
1995 – today Memberships: Greek Chemists Association, Marie-Curie Fellowship Association (Hellenic MCFA, Vice-Chair, 2006- 2008), European Peptide Society (Greek Effective Member in EPS, 2014- ), Ampere Committee Member (2016-  ), Hellenic Society for Biochemistry & Molecular Biology, Hellenic Society for Computational Biology and Bioinformatics, Hellenic Crystallographic Association

 

teaching activities
2003 – today Teaching position – “Design/Simulation of Bioactive molecules with Pharmaceutical Interest”, Biochemistry, NMR Spectroscopy topic in Instrumental Analysis & Spectroscopy, General Chemistry, (bio)Informatics

 

SUPERVISION OF GRADUATE STUDENTS and POSTDOCTORAL FELLOWS  (if applicable)
2003 – today 11 Post-docs, 3 Post-Docs today; 11 PhDs (completed) & 6 On-going; 53 Master Students (completed) & 8 Οn-going

 
FELLOWSHIPS and AWARDS
11.1989 -10.1994 « EMY » Fellowship for PhD research, Ministry of Education, Univ. of Crete, GREECE;
1993 « DIGITAL CORPORATION AWARD » for Achievement in PhD Research, Univ of Crete, GREECE
11.1996 – 12.1996 « CLAUDE BERNARD Fondation » Grant (U René Descartes, Paris, FRANCE ;).
11.1997 – 12.1999 « Marie-Curie Post-Doctoral Research Training Grant», Center of Magnetic Resonance (CERM), Univ. of Florence, ITALY
05.2000 – 04.2001 « Marie-Curie Return Grant», School of Health Sciences, Dept of Pharmacy, Univ of Patras, GREECE
05.2002 – 04.2003 « C. Caratheodory Post-Doctoral Grant», Dept of Pharmacy, Univ of Patras, GREECE
05.2003 – 08.2003 ΕΜΒΟ Short-term Research Grant, Center of Magnetic Resonance (CERM), Univ. of Florence, ITALY
05.2004 – 08.2004 ΕΜΒΟ Short-term Research Grant, Center of Magnetic Resonance (CERM), Univ. of Florence, ITALY
 

 

  
MAIN research Grants (grey highlights the EU-GRANTS;  TOTAL Budget  > 11.00 M€)
Project Title Funding source Period Role of the PI
Marie Curie Research Training Grant, “NMR Spectroscopy to study the factors controlling the folding/unfolding process in Paramagnetic Metalloproteins” EU-FP6, Contract No : ERBFMBICT 972477. 1997-1999 Grant Holder
Marie Curie Return Grant, “NMR Structural Studies of Chemically Modified c-Cytochromes as a probe of Protein Folding Pathways” EU-FP6, Contract No : HPMF-CT-1999-00344. 2000-2001 Grant Holder
INNO-FARM – Joint Research & Technological development Program of West Greece” GSRT, Ministry of Development, GREECE 2006-2008 Co-Investigator
FP7-HEALTH-2007-2.1.1-5. “NEUROCYPRES: Neurotrasmitter Cys-loop receptors: structure, function and disease (NeuroCypress)” EU-FP7, HEALTH-F4-2008 – 202088 2008-2012 Principal Investigator, UPAT’s Team Leader
FP7-INFRA-2008-1.1.1., “EAST-NMR: Enhancing Access and Services To East European users towards an efficient and coordinated pan-European pool of NMR capacities to enable global collaborative research and boost technological advancements” EU-FP7, Research Infrastructures, CP-CSA-Infra-228461 2009-2013 Principal Investigator, UPAT’s Team Leader
HERACLITUS ΙΙ: “Expression, Characterization and Structural Investigation through Nuclear Magnetic Resonance (NMR) of the Bacillus anthracis Anthrax Lethal Factor Zn-protease Catalytic Site” Greek Ministry of Education, GREECE 2011-2014. Principal Investigator
GSRT- THALIS: “Hydrogen sulfide, a new endogenous regulator of angiogenesis: signaling, physiology/pathophysiology and development of pharmacological inhibitors” GSRT & Greek Ministry of Education, GREECE 2011-2015 Co-Investigator
FP7-REGPOT-2011-1. SEE-DRUG: Establishment of Centre of Excellence for Structure-Based Drug Target Characterization: Strengthening the Research Capacity of South-Eastern Europe EU-FP7, Capacities – Research Potential, CT-2011-285950 2012-2015.  Coordinator
National Greek Roadmap of Research Infrastructures (RIs) – RI: “INSPIRED” GSRT & Ministry of Development, GREECE 2018-2021 Coordinator of UPAT’s Project (“UPAT-RISF”)
National Greek Roadmap of Research Infrastructures (RIs) – RI: “OMIC-ENGINE” GSRT & Ministry of Development, GREECE 2017-2021 Principal Investigator, UPAT’s Team Leader
H2020-BG-2014-2, BG-03-2014 – “MARISURF: Novel, Sustainable marine Bio-surfactant/Bio-emulsifiers for commercial exploitation EU-H2020, No 635340 2015-2020 Principal Investigator, UPAT’s Team Leader
H2020 – H2020-INFRAIA-2014-2015 – “iNEXT: Infrastructure for NMR, EM and X-ray crystallography for translational research”, EU-H2020, No 653706 2015-2020 Principal Investigator, UPAT’s Team Leader
NSRF 2014-2020, “The impact of the catalytic region of the E3 ubiquitin ligase Arkadia in function and diagnosis” GSRT & Ministry of Development, GREECE 2017-2019 Principal Incvestigator
H2020-MSCA-IF-2017 – “NMRSIGN: NMR insights on the soluble Guanylyl Cyclase conformational dynamics to illuminate the SIGNaling pathway” EU-H2020, MARIE SKŁODOWSKA-CURIE ACTIONS 2018-2020 Co-Supervisor & PI of the Coordinating Organization
RESEARCH–CREATE-INNOVATE, MIS 5067545, – “POLYPEPPHARM: Improved generic polypeptide drugs with innovative pharmaceutical forms – Τ2ΕΔΚ-00996” GSRT & Ministry of Development, GREECE 2020-2023 Co-Investigator
HORIZON-INFRA-2021-DEV-01 – “Remote NMR (R-NMR): Moving NMR infrastructures to remote access capabilities”, (https://r-nmr.eu/), EU HORIZON EUROPE, INFRASTRUCTURES, GA 101058595 2022-2025 WP Leader & Member of the Steering Board
HORIZON–WIDERA-2022-TALENTS-01 ERA Chairs (European Union) – “ESPERANCE: the ERA Chair Life Sciences Program to EmpoweR moleculAr aNd struCtural biology initiativEs at UPAT”, (https://era-esperance.eu/) EU HORIZON EUROPE, WIDERA, GA 101087215 (DOI 10.3030/101087215 ), 2023-2028 Coordinator
 HORIZON-MSCA-2022-SE-01– “RIA4FOOD: Multi-Actor Research and Innovation Approaches for Functional Foods”, (https://ria4food.eu/) EU HORIZON EUROPE, MSCA STAFF EXCHANGE, GA 101131479, 2023-2027 WP Leader & PI (UPAT)
 HORIZON-CL6-2022-CIRCBIO-02-two-stages – “TOLERATE: Adaptation to climate change in the rhizosphere across the millennia”, (https://tolerate-eu-project.com/), EU HORIZON EUROPE, Circular Economy and Environment, GA 101082049 (DOI 10.3030/101082049), 2023-2027 PI (UPAT)
 HORIZON-WIDERA-2023-ACCESS-04 – “MILESTONE: UpstreaM synergIes to overcome Locked-in effects in widEning regions and broaden internationalization pathwayS for susTainable innOvatioN and compEtitive grant applications”, (https://milestone-he.eu/), EU HORIZON EUROPE, WIDERA, GA 101159708 (DOI: 10.3030/101159708), 2024-2027 Coordinator
HFRI 2nd H.F.R.I. Call for the Procurement of High-value Research Equipment – “iMELODY – iMplementation of nEw tooLs to bOost the Drug discoverY pipeline at the Department of Pharmacy/UPAT” Hellenic Foundation for Research & Innovation, GR, GA 18879. 2025-2027 Co-Investigator
HFRI 3rd Call for H.F.R.I.’s Research Projects to Support Faculty Members & Researcher – “TALENT: Novel Soluble GuanylaTe Cyclase StimulAtors: RationaL Design-Driven Optimization and CharactErization of their Unique MechaNism of AcTion” Hellenic Foundation for Research & Innovation, GR, GA 26699 2025-2028 Coordinator
 HORIZON-MSCA-2024-SE-01 – “GuardAgents: Study of Novel Generation nanobodies for agri-food applications”, EU HORIZON EUROPE, MSCA STAFF EXCHANGE, GA 101236168 2025-2029 WP Leader & PI