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Research Articles

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Group’s Publications in peer-reviewed scientific journals since 2006:

Jan 04

74. Organotin derivatives of cholic acid; Synthesis, characterizations and bioinorganic evaluation. Steroids 167, 108798, (2021)

74. M-E.K. Stahopoulou, N. Zoupanou, C.N. Banti, A. Douvalis, C. Papachristodoulou, K.D. Marousis, G.A. Spyroulias, T. Mavromoustakos, S.K. Hadjikakou. Organotin derivatives of cholic acid; Synthesis, characterizations and bioinorganic evaluation. Steroids 167, 108798, (2021). https://doi.org/10.1016/j.steroids.2021.108798

Jan 04

73. 1H, 13C, and 15N chemical shift assignments of the SUD domains of SARS-CoV-2 non-structural protein 3c: “The SUD-M & SUD-C domains”. Biomol. NMR Assign.  15, 165-171, (2021)

73. Α. Gallo, A.C. Tsika, N.K. Fourkiotis, F. Cantini F, L. Banci,  S. Sreeramulu, H. Schwalbe, G.A. Spyroulias. 1H, 13C, and 15N chemical shift assignments of the SUD domains of SARS-CoV-2 non-structural protein 3c: “The SUD-M & SUD-C domains”. Biomol. NMR Assign.  15, 165-171, (2021). https://doi.org/10.1007/s12104-020-10000-9

Jan 04

72. 1H, 13C, and 15N chemical shift assignments of the SUD domains of SARS-CoV-2 non-structural protein 3c: “The N-terminal domain-SUD-N”. Biomol. NMR Assign.  15, 85-89 (2021)

72. Α. Gallo, A.C. Tsika, N.K. Fourkiotis, F. Cantini F, L. Banci,  S. Sreeramulu, H. Schwalbe, G.A. Spyroulias. 1H, 13C, and 15N chemical shift assignments of the SUD domains of SARS-CoV-2 non-structural protein 3c: “The N-terminal domain-SUD-N”. Biomol. NMR Assign.  15, 85-89 (2021). https://doi.org/10.1007/s12104-020-09987-y

Jan 04

71. 1H, 13C and 15N backbone and side-chain resonance assignment of Nostoc sp. C139A variant of the Heme-Nitric Oxide/Oxygen Binding(H-NOX) domain in complex with cinaciguat (BAY 58-2667). Biomol. NMR Assign.  15, 53-57 (2021)

71. G. Dalkas, G.I.  Makrynitsa, A. Argyriou, M. Bantzi, S. Topouzis, P. Sandner, A. Giannis, A. Papapetropoulos, G.A. Spyroulias.  1H, 13C and 15N backbone and side-chain resonance assignment of Nostoc sp. C139A variant of the Heme-Nitric Oxide/Oxygen Binding(H-NOX) domain in complex with cinaciguat (BAY 58-2667). Biomol. NMR Assign.  15, 53-57 (2021). https://doi.org/10.1007/s12104-016-9707-6

Jan 04

70. A quantitative western blot technique using TMB: Comparison with a free quantification software. Electrophoresis  42, 786-792  (2021)

70. Α. Ntoukas, A. Niarchos, A.C. Tsika, S. Mantzoukas, G.A. Spyroulias,, K. Poulas.  A quantitative western blot technique using TMB: Comparison with a free quantification software. Electrophoresis  42, 786-792  (2021).  https://doi.org/10.1002/elps.202000306

Jan 04

69. Assessment of biodistribution of TAT-L-Sco2 Fusion Protein, towards a Protein Therapeutic approach for Mitochondrial Neurodegenerative Disorders, due to SCO2 Mutations. Mol. Genet. Metab. Rep., 25, 100683, (2020)

69. G.C. Kaiafas, D. Papagiannopoulou, Α.N. Miliotou, A.S. Tsingotjidou, P.C. Chalkidou, A.C. Tsika, G.A. Spyroulias, A.S. Tsiftsoglou, L.C. Papadopoulou. Assessment of biodistribution of TAT-L-Sco2 Fusion Protein, towards a Protein Therapeutic approach for Mitochondrial Neurodegenerative Disorders, due to SCO2 Mutations. Mol. Genet. Metab. Rep., 25, 100683, (2020). https://doi.org/10.1016/j.ymgmr.2020.100683

Jan 04

68. Identification of compounds that bind the centriolar protein SAS-6 and inhibit its oligomerisation. J. Biol. Chem. 295, 17922-17934, (2020)

68. J.M.C. Busch, M.-T. Matsoukas, M. Musgaard, G.A. Spyroulias, P.C. Biggin, I. Vakonakis. Identification of compounds that bind the centriolar protein SAS-6 and inhibit its oligomerisation. J. Biol. Chem. 295, 17922-17934, (2020). https://doi.org/10.1074/jbc.RA120.014780

Jan 04

67. Functional and structural aspects of La overexpression in lung cancer. J. Mol. Biol. 432, 166712 (2020)

67. E. Kaliatsi, A. Argyriou, G. Bouras, M. Apostolidi, P. Konstantinidou, A.-N. Sokat, G.A. Spyroulias, C. Stathopoulos. Functional and structural aspects of La overexpression in lung cancer. J. Mol. Biol. 432, 166712 (2020). https://doi.org/10.1016/j.jmb.2020.11.011

Jan 04

66. Discovery of a stable tripeptide targeting the N-domain of CRF1 receptor. Amino Acids  52, 1337-1351 (2020)

66. G. Liapakis, V. Karageorgos, J. Andreadelis, G.G. Holz, E. Dermitzaki, G.G. Kordopati, E.K. Stylos, K. Spyridaki, S. Poulaki, D. Ntountaniotis, S. Sakellaris, M. Vanioti, A. Kostagianni, K.D. Marousis, G. Leonis, G. Kokotos, M. Venihaki, G.A. Spyroulias, T. Tselios, A. Margioris, A. Tzakos, Τ. Mavromoustakos.  Discovery of a stable tripeptide targeting the N-domain of CRF1 receptor. Amino Acids  52, 1337-1351 (2020). https://doi.org/10.1007/s00726-020-02895-4

Jan 04

65. H, 13C, and 15N backbone chemical shift assignments of the apo and the ADP-ribose bound forms of the macrodomain of SARS-CoV-2 non-structural protein 3b Biomol. NMR Assign.  14, 339-346 (2020)

65. F. Cantini, L. Banci, N. Altincekic, J.K. Bains, K. Dhamotharan, C. Fuks, B. Fürtig, S.L. Gande, B. Hargittay, M. Hengesbach, M.T. Hutchison, S.M. Korn, N. Kubatova, F. Kutz, V. Linhard, F. Löhr, N. Meiser, D.J. Pyper, N.S. Qureshi, C. Richter, K. Saxena, A. Schlundt, H. Schwalbe, S. Sreeramulu, J.N. Tants, A. Wacker, J.E. Weigand, J. Wöhnert, A.C. Tsika, N. Fourkiotis, G.A. Spyroulias. 1H, 13C, and 15N backbone chemical shift assignments of the apo and the ADP-ribose bound forms of the macrodomain of SARS-CoV-2 non-structural protein 3b. Biomol. NMR Assign.  14, 339-346 (2020).  https://doi.org/10.1007/s12104-020-09973-4

Jan 04

64. Unsaturated fatty acid-induced conformational transitions and aggregation of the repeat domain of Tau. Molecules  25, 2716 (1-21), (2020)

64. C.G. Barracchia, R. Tira, F. Parolini, F. Munari, L. Bubacco, G.A. Spyroulias, M. D’Onofrio, M. Assfalg. Unsaturated fatty acid-induced conformational transitions and aggregation of the repeat domain of Tau. Molecules  25, 2716 (1-21), (2020). https://doi.org/10.3390/molecules25112716

Jan 04

63. Marine-Derived Surface Active Agents: Health-Promoting Properties and Blue Biotechnology-Based Applications. Biomolecules  10, 885 (1-27), (2020)

63. I. Anestopoulos, D.-E. Kiousi, A. Klavaris, M. Maijo, A. Serpico, A. Suarez, G. Sanchez, K. Salek, S. A. Chasapi, A. A. Zompra, A. Galanis, G. A. Spyroulias, S. R. Euston, L. Gombau, A. Pappa, M.I. Panayiotidis. Marine-Derived Surface Active Agents: Health-Promoting Properties and Blue Biotechnology-Based Applications. Biomolecules  10, 885 (1-27), (2020). https://doi.org/10.3390/biom10060885

Jan 04

62. Metabolic changes in early neonatal life: NMR analysis of the neonatal metabolic profile to monitor postnatal metabolic adaptations. Metabolomics  16, 58 (1-12), (2020)

62. I. Georgakopoulou, S.A. Chasapi, S.E. Bariamis, A. Varvarigou, M. Spraul, G.A. Spyroulias. Metabolic changes in early neonatal life: NMR analysis of the neonatal metabolic profile to monitor postnatal metabolic adaptations. Metabolomics  16, 58 (1-12), (2020).  https://doi.org/10.1007/s11306-020-01680-4

Jan 04

61. 1H, 13C and 15N Backbone and side-chain resonance assignment of UbcH7 E2 Ubiquitin Conjugating Enzyme. Biomol. NMR Assign.  14, 73-78, (2020)

61. K. Marousis, M. Birkou, A. Asimakopoulou, G.A. Spyroulias. 1H, 13C and 15N Backbone and side-chain resonance assignment of UbcH7 E2 Ubiquitin Conjugating Enzyme. Biomol. NMR Assign.  14, 73-78, (2020). https://doi.org/10.1007/s12104-019-09923-9

Jan 04

60. Deciphering the nucleotide and RNA binding selectivity of the Mayaro virus macro domain. J. Mol. Biol.  431, 2282-2296, (2019)

60. A.C. Tsika, S. Melekis, S.-A. Tsatsouli, N. Papageorgiou, M.J. Maté, B. Canard, B. Coutard, D. Bentrop, G.A. Spyroulias. Deciphering the nucleotide and RNA binding selectivity of the Mayaro virus macro domain. J. Mol. Biol.  431, 2282-2296, (2019). https://doi.org/10.1016/j.jmb.2019.04.013

Jan 04

59. Conformational plasticity of the VEEV macro domain is important for binding of ADP-ribose. J. Struct. Biol.  206, 119-127, (2019)

59. G.I.  Makrynitsa, D. Ntonti, K.D. Marousis, M. Birkou, M.-T. Matsoukas, S. Asami, D. Bentrop, N. Papageorgiou, B. Canard, B. Coutard, G.A. Spyroulias. Conformational plasticity of the VEEV macro domain is important for binding of ADP-ribose. J. Struct. Biol.  206, 119-127, (2019). https://doi.org/10.1016/j.jsb.2019.02.008

Jan 04

58. Biosynthesis of rhamnolipid by a Marinobacter species expands the paradigm of biosurfactant synthesis to a new genus of the marine microflora. Microb. Cell Fact.  18, 164, (2019)

58. L. Tripathi, M. Twigg, A. Zompra, K. Salek, V.U. Irorere, T. Gutierrez, G.A. Spyroulias, R. Marchant, I.M. Banat. Biosynthesis of rhamnolipid by a Marinobacter species expands the paradigm of biosurfactant synthesis to a new genus of the marine microflora. Microb. Cell Fact.  18, 164, (2019). https://doi.org/10.1186/s12934-019-1216-8

Jan 04

57. Novel stable analogues of the Neurotensin C-terminal hexapeptide containing unnatural amino acids. Amino Acids  51, 1009-1022, (2019).

57. V. Magafa, M.-T. Matsoukas, V. Karageorgos, E. Dermitzaki, R. Exarchakou, E.K. Stylos, M. Pardalos, A.N. Margioris, G. Varvounis, A.G. Tzakos, G.A. Spyroulias, G. Liapakis. Novel stable analogues of the Neurotensin C-terminal hexapeptide containing unnatural amino acids. Amino Acids  51, 1009-1022, (2019).  https://doi.org/10.1007/s00726-019-02741-2

Jan 04

56. Therapeutic Targeting of the Soluble Guanylate Cyclase. Curr. Med. Chem.  26, 2730-2747, (2019)

56. G. Makrynitsa, A. Argyriou, A. Zompra, G.A. Spyroulias, S. Topouzis. Therapeutic Targeting of the Soluble Guanylate Cyclase. Curr. Med. Chem.  26, 2730-2747, (2019). 10.2174/0929867326666190108095851

Jan 04

55. Identification and Characterisation of Short Chain Rhamnolipid Production in a Previously Uninvestigated, Non-Pathogenic Marine Pseudomonad. Applied Microbiol. Biotechnol. 102, 8537-49

55. M.S. Twigg, L. Tripathi, A. Zompra, K. Salek, V.U. Irorere, T. Gutierrez, G.A. Spyroulias, R. Marchant, I.M. Banat. Identification and Characterisation of Short Chain Rhamnolipid Production in a Previously Uninvestigated, Non-Pathogenic Marine Pseudomonad. Applied Microbiol. Biotechnol. 102, 8537-49, (2018).  10.1007/s00253-018-9202-3

Jan 04

54. Lead Identification through the synergistic action of Biomolecular NMR and in silico methodologies. Methods Mol. Biol.  1824, 299-316

54. K.D. Marousis, A.C. Tsika, M. Mbirkou, M.-T. Matsoukas, G.A. Spyroulias. Lead Identification through the synergistic action of Biomolecular NMR and in silico methodologies. Methods Mol. Biol.  1824, 299-316, (2018). https://doi.org/10.1007/978-1-4939-8630-9_18

Jan 04

53. iNEXT: a European facility network to stimulate translational structural biology

53. iNEXT Consortium. iNEXT: a European facility network to stimulate translational structural biology. FEBS Lett  592, 1909-1917 (2018). https://doi.org/10.1002/1873-3468.13062

Jan 04

52. Triazole pyrimidine nucleosides are potent inhibitors of human Angiogenin in vivo. Evidence for novel action at the cell binding site revealed by heteronuclear NMR spectroscopy and modelling studies. ChemMedChem  13, 259-269, (2018)

52. D.S.M. Chatzileontiadou, A.C. Tsika, Z. Diamantopoulou, J. Delbé, J. Badet, J. Courty, V. Parmenopoulou, D. Komiotis, J.M. Hayes, G.A. Spyroulias, D.D. Leonidas. Triazole pyrimidine nucleosides are potent inhibitors of human Angiogenin in vivo. Evidence for novel action at the cell binding site revealed by heteronuclear NMR spectroscopy and modelling studies. ChemMedChem  13, 259-269, (2018).  10.1002/cmdc.201700688

Jan 04

51. NMR study of non-structural proteins – Part III. 1H, 13C, 15N backbone and side-chain resonance assignment of macro domain from Chikungunya virus (VEEV)

51. M. Lykouras, A.C. Tsika, J. Lichière, N. Papageorgiou, B. Coutard, G.A. Spyroulias. NMR study of non-structural proteins – Part III. 1H, 13C, 15N backbone and side-chain resonance assignment of macro domain from Chikungunya virus (VEEV). Biomol. NMR Assign. 12, 31-35, (2018). https://doi.org/10.1007/s12104-017-9775-2

Jan 04

50. Pleiotropic Effects of Apolipoprotein C3 on HDL Functionality and Adipose Tissue Metabolic Activity. J. Lipid Res.  58, 1869-1883

50. E. Zvintzou, M. Lhomme, S.A. Chasapi, S. Filou, V. Theodoropoulos, E. Xapapadaki, A. Kontush, G.A. Spyroulias, K.E. Kypreos. Pleiotropic Effects of Apolipoprotein C3 on HDL Functionality and Adipose Tissue Metabolic Activity. J. Lipid Res.  58, 1869-1883, (2017). https://doi.org/10.1194/jlr.M077925

Jan 04

49. A residue-specific insight into the Arkadia E3 ubiquitin ligase activity and conformational plasticity. J. Mol. Biol.429, 2373-2386

49. M. Birkou, C.T. Chasapis, K.D. Marousis, A.K. Loutsidou, D. Bentrop, M. Leli, T. Herrmann, Carthy JM, V. Episkopou, G.A. Spyroulias. A residue-specific insight into the Arkadia E3 ubiquitin ligase activity and conformational plasticity. J. Mol. Biol.429, 2373-2386 (2017). https://doi.org/10.1016/j.jmb.2017.06.012

Jan 04

48. Dynamic properties of the Growth Hormone Releasing Hormone Receptor (GHRHR) and molecular determinants of GHRH binding. Mol. Biosyst. 13, 1313-1322

48. M-T. Matsoukas & G.A. Spyroulias. Dynamic properties of the Growth Hormone Releasing Hormone Receptor (GHRHR) and molecular determinants of GHRH binding. Mol. Biosyst. 13, 1313-1322 (2017). https://doi.org/10.1039/C7MB00130D

Jan 04

47. Plasma and serum metabolite association networks: comparability within and between studies using NMR and MS profiling

47. M. Suarez-Diez, J. Adam, J. Adamski, S.A. Chasapi, C. Luchinat, A. Peters, C. Prehn, C. Santucci, A. Spyridonidis, G.A. Spyroulias, L. Tenori, R. Wang-Sattler, E. Saccenti. Plasma and serum metabolite association networks: comparability within and between studies using NMR and MS profiling. J. Proteome Res.  16, 2547-2559, (2017). https://doi.org/10.1021/acs.jproteome.7b00106

Jan 04

46. A combined NMR and molecular dynamics simulation study to determine the conformational properties of rat/mouse 35-55 Myelin Oligodentrocyte Glycoprotein epitope implicated in the induction of Experimental Autoimmune Encephalomyelitis

46. D. Ntountaniotis, Μ. Vanioti, G.G. Kordopati, T.F. Kellici, K.D. Marousis, T. Mavromoustakos, G.A. Spyroulias, S.Golic Grdadolnik, T.V. Tselios. A combined NMR and molecular dynamics simulation study to determine the conformational properties of rat/mouse 35-55 Myelin Oligodentrocyte Glycoprotein epitope implicated in the induction of Experimental Autoimmune Encephalomyelitis. J. Biomol. Structure & Dynamics  35, 1559-67 (2017). https://doi.org/10.1080/07391102.2016.1188418

Jan 04

45. 1H, 13C and 15N backbone and side-chain resonance assignment of Nostoc sp. C139A variant of the Heme-Nitric Oxide/Oxygen Binding(H-NOX) domain

45. I.I. Alexandropoulos, A. Argyriou, K. Marousis, S. Topouzis, A. Papapetropoulos, G.A.Spyroulias. 1H, 13C and 15N backbone and side-chain resonance assignment of Nostoc sp. C139A variant of the Heme-Nitric Oxide/Oxygen Binding(H-NOX) domain. Biomol. NMR Assign. 10, 395-400 (2016). 10.1007/s12104-016-9707-6