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Research Articles

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Group’s Publications in peer-reviewed scientific journals since 2006:

Jan 04

104. E2 partner tunes ubiquitination specificity of Arkadia E3 Ubiquitin Ligase. Cancers (2023).

104. N. Delegkou, M. Birkou, N. Fragkaki, T.I. Munoz Toro, K.D. Marousis, V. Episkopou, G.A. Spyroulias. E2 partner tunes ubiquitination specificity of Arkadia E3 Ubiquitin Ligase. Cancers (2023).

Jan 04

103. NMR analysis suggests synergy between the RRM2 and carboxy-terminus segment of human La protein in the recognition and interaction with HCV IRES. International Journal of Molecular Sciences. (2023).

103. I. Argyriou, G. Mahaliotis, G. I. Makrynitsa, E. Kaliatsi, C. Stathopoulos, G.A.Spyroulias. NMR analysis suggests synergy between the RRM2 and carboxy-terminus segment of human La protein in the recognition and interaction with HCV IRES. International Journal of Molecular Sciences. (2023).

Jan 04

102. McIdas localizes at centrioles and controls centriole numbers through PLK4-dependent phosphorylation. Cell Reports, submitted (2023)

102. M. Arbi, M. Skamnelou, S. Bournaka, S. Zitouni, S. Tsaridou, O. Karayel, C.G. Vasilopoulou, A.C. Tsika, N.N. Giakoumakis, G.A. Spyroulias, M. Mann, M. Bettencourt-Dias, S. Taraviras, Zoi Lygerou. McIdas localizes at centrioles and controls centriole numbers through PLK4-dependent phosphorylation. Cell Reports, submitted (2023).

Jan 04

101. Peptide Inhibitors of Angiotensin-I Converting Enzyme Based on Angiotensin (1–7) with Selectivity for the C-terminal Domain. Bioorganic Chemistry 129, 106124 (2022)

101. Ρ.L. da Silva; A.Papakyriakou; A.K. Carmona; G.A. Spyroulias; E.D. Sturrock; P.A. Bersanetti, Cl.R. Nakaie. Peptide Inhibitors of Angiotensin-I Converting Enzyme Based on Angiotensin (1–7) with Selectivity for the C-terminal Domain. Bioorganic Chemistry 129, 106124 (2022). https://doi.org/10.1016/j.bioorg.2022.106204

Jan 04

100. 1H, 13C, 15N backbone resonance assignment of apo and ADP-ribose bound forms of the macro domain of Hepatitis E virus through solution NMR Spectroscopy. Biomol. NMR Assign.  00000 (2022)

100. M.D. Politi, A. Gallo, G. Bouras, M. Birkou, B. Canard, B. Coutard, G.A. Spyroulias. 1H, 13C, 15N backbone resonance assignment of apo and ADP-ribose bound forms of the macro domain of Hepatitis E virus through solution NMR Spectroscopy. Biomol. NMR Assign.  00000 (2022). https://doi.org/10.1007/s12104-022-10111-5

Jan 04

99. NMR-based metabolomic profiling of children with Premature Adrenarche. Metabolomics 18, 78 (2022)

99. K. Matzarapi, S.Α. Chasapi, D. Kritikou, A. Giannakopoulos, A. Efthymiadou, D. Chrysis, G.A. Spyroulias. NMR-based metabolomic profiling of children with Premature Adrenarche. Metabolomics 18, 78 (2022). https://doi.org/10.1007/s11306-022-01941-4

Jan 04

98. Multi-method biophysical analysis in discovery, identification and in-depth characterization of surface‐active compounds. Frontiers in Marine Science, Special Issue “Biotechnology of Marine Microorganisms”, 9, 1023287 (2022)

98. A.A. Zompra, S.A. Chasapi, M. Twigg, K. Salek, I. Anestopoulos, A. Galanis, A. Pappa, T. Gutierrez, I. Banat, R. Marchant, S.R. Euston, M.I. Panayiotidis, G.A.Spyroulias. Multi-method biophysical analysis in discovery, identification and in-depth characterization of surface‐active compounds. Frontiers in Marine Science, Special Issue “Biotechnology of Marine Microorganisms”, 9, 1023287 (2022). https://doi.org/10.3389/fmars.2022.1023287

Jan 04

97. Comprehensive fragment screening of the SARS-CoV-2 proteome explores novel chemical space for drug development.  Angewandte Chemie Int Ed Engl 61, e202205858 (2022)

97. COVID19-NMR Consortium, and Α.C. Tsika, N.K. Fourkiotis, A. Gallo, G.A. Spyroulias.  Comprehensive fragment screening of the SARS-CoV-2 proteome explores novel chemical space for drug development.  Angewandte Chemie Int Ed Engl 61, e202205858 (2022). https://doi.org/10.1002/anie.202205858

Jan 04

96. NMR study of human macroPARPs domains: 1H, 15N and 13C resonance assignment of hPARP14 macro domain 2 in the free and the ADPr bound state. Biomol. NMR Assign.  16, 399-406 (2022)

96. N.K. Fourkiotis, P. Charalampous, A.C. Tsika, K.P. Kravvariti, Ch. Sideras, Α. Gallo, G.A. Spyroulias. NMR study of human macroPARPs domains: 1H, 15N and 13C resonance assignment of hPARP14 macro domain 2 in the free and the ADPr bound state. Biomol. NMR Assign.  16, 399-406 (2022).    https://doi.org/10.1007/s12104-022-10110-6

Jan 04

95. Unveiling Arkadia’s non-RING elements with essential role in the ubiquitination mechanism. International Journal of Molecular Sciences, 23, 10585 (2022)

95. M. Birkou, G.N. Delegkou, K.D. Marousis, N. Fragkaki, T.I. Munoz Toro, V. Episkopou, G.A. Spyroulias. Unveiling Arkadia’s non-RING elements with essential role in the ubiquitination mechanism. International Journal of Molecular Sciences, 23, 10585 (2022).  https://doi.org/10.3390/ijms231810585

Jan 04

94. Backbone and side chain NMR assignment of the heme-nitric oxide/oxygen binding (H-NOX) domain from Nostoc punctiforme. Biomol. NMR Assign.  16, 379-384 (2022)

94. S.A. Chasapi, Α.I. Argyriou, G.A. Spyroulias. Backbone and side chain NMR assignment of the heme-nitric oxide/oxygen binding (H-NOX) domain from Nostoc punctiforme. Biomol. NMR Assign.  16, 379-384 (2022). https://doi.org/10.1007/s12104-022-10107-1

Jan 04

93. Binding adaption of GS-441524 diversifies macro domains and downregulate SARS-CoV-2  de-MARylation capacity. J. Mol. Biol. 434, 167720 (2022

93. Α.C. Tsika, A. Gallo, N.K. Fourkiotis, A.I. Argyriou, S. Sreeramulu, F. Löhr, V.V. Rogov, C. Richter, V. Linhard, S.L. Gande, N. Altincekic, R. Krishnathas, I. Elamri, H. Schwalbe, J. Wollenhaupt, M.S. Weiss, G.A. Spyroulias. Binding adaption of GS-441524 diversifies macro domains and downregulate SARS-CoV-2  de-MARylation capacity. J. Mol. Biol. 434, 167720 (2022). https://doi.org/10.1016/j.jmb.2022.167720

Jan 04

92. Structural perspectives on sGC stimulators’ binding to H-NOX domain regulated by the redox state of the heme. Front. Cell Develop. Biol.10, 925457, (2022)

92. I. Makrynitsa, A.I. Argyriou, A. Zompra, K. Salagiannis, V. Vazoura, A. Papapetropoulos, S.Topouzis, G.A. Spyroulias. Structural perspectives on sGC stimulators’ binding to H-NOX domain regulated by the redox state of the heme. Front. Cell Develop. Biol.10, 925457, (2022). https://doi.org/10.3389/fcell.2022.925457

Jan 04

91. NMR-based metabolomics in differential diagnosis of chronic kidney disease (CKD) subtypes. Metabolites 12, 490 (2022)

91. S.A. Chasapi, E. Karagkouni, D. Kalavryzioti, S. Vamvakas, A. Zompra, P.G. Takis, D. Goumenos, G.A. Spyroulias. NMR-based metabolomics in differential diagnosis of chronic kidney disease (CKD) subtypes. Metabolites 12, 490 (2022). https://doi.org/10.3390/metabo12060490

Jan 04

90. Losartan interactions with 2-hydroxypropyl-β-CD. Molecules 27, 2421 (2022)

90. V. Palli, G. Leonis, N. Zoupanou, N. Georgiou, M. Chountoulesi, N. Naziris, D. Tzeli, C. Demetzos, G. Valsami G. Spyroulias, T. Mavromoustakos. Losartan interactions with 2-hydroxypropyl-β-CD. Molecules 27, 2421 (2022).   https://doi.org/10.3390/molecules27082421

Jan 04

89. Impact of a single nucleotide polymorphism on the 3D protein structure and ubiquitination activity of E3 ubiquitin ligase Arkadia.  Front. Mol. Biosci.  9, 844129 (2022)

89. M. Birkou, V. Raptis, K.D. Marousis, A. Tsevis, K. Bourikas, D. Bentrop, V. Episkopou, G.A. Spyroulias. Impact of a single nucleotide polymorphism on the 3D protein structure and ubiquitination activity of E3 ubiquitin ligase Arkadia.  Front. Mol. Biosci.  9, 844129 (2022). 10.3389/fmolb.2022.844129

Jan 04

88. Untargeted 1H-NMR urine metabolomics analysis of preterm infants with neonatal sepsis. Applied Science 12(4), 1932 (2022)

88. P.D. Georgiopoulou, S.A. Chasapi, I. Christopoulou, A. Varvarigou, G.A. Spyroulias. Untargeted 1H-NMR urine metabolomics analysis of preterm infants with neonatal sepsis. Applied Science 12(4), 1932 (2022), https://doi.org/10.3390/app12041932

Jan 04

87. The 1H, 13C and 15N backbone resonance assignment of SARS-CoV and MERS-CoV macro domains in free and in the ADPr-bound forms. Biomol. NMR Assign. 16, 9-16 (2022)

87. A.C. Tsika, N.K. Fourkiotis, P. Charalampous, Α. Gallo, G.A. Spyroulias. The 1H, 13C and 15N backbone resonance assignment of SARS-CoV and MERS-CoV macro domains in free and in the ADPr-bound forms. Biomol. NMR Assign. 16, 9-16 (2022). https://doi.org/10.1007/s12104-021-10052-5

Jan 04

86. Metabolite and bioactive compounds profiling of Meteora Sea Buckthorn berries through high-resolution NMR Analysis. Metabolites 11, 822 (2021)

86. A.A. Zompra, S.A. Chasapi, E. Karagkouni, E. Karamouzi, P. Panopoulos, G.A. Spyroulias. Metabolite and bioactive compounds profiling of Meteora Sea Buckthorn berries through high-resolution NMR Analysis. Metabolites 11, 822 (2021). https://doi.org/10.3390/metabo11120822

Jan 04

85. Replacement of heme by soluble guanylate cyclase (sGC) activators abolishes HNOX domain structural plasticity. Curr. Res. Struct. Biol. 3, 324-336 (2021)

85. A.I. Argyriou, G. I. Makrynitsa, G. Dalkas, D. Georgopoulou, K. Salagiannis, V. Vazoura, A. Papapetropoulos, S. Topouzis, G.A. Spyroulias. Replacement of heme by soluble guanylate cyclase (sGC) activators abolishes HNOX domain structural plasticity. Curr. Res. Struct. Biol. 3, 324-336 (2021).  https://doi.org/10.1016/j.crstbi.2021.11.003

Jan 04

84. Structure activity relationship of the binding of p-coumaroyl glucose to glycogen phosphorylase and its effect on hepatic cell metabolic pathways. Eur. J. Med. Chem. Reports   3, 100011 (2021).

84. A.S. Tsagkarakou, S.A. Chasapi, S.M. Koulas, I. Tsialtas, E. Kyriakis, C.E. Drakou, S. Kun, L. Somsák, G.A. Spyroulias, A.-M.G. Psarra, D.D. Leonidas. Structure activity relationship of the binding of p-coumaroyl glucose to glycogen phosphorylase and its effect on hepatic cell metabolic pathways. Eur. J. Med. Chem. Reports   3, 100011 (2021). https://doi.org/10.1016/j.ejmcr.2021.100011

Jan 04

83. 3D Reconstitution of the Neural Stem Cell Niche: Connecting the Dots. Front. Bioeng. Biotechnol. 9, 705470 (2021)

83. K. Ioannidis, I. Angelopoulos, G. Gakis, N. Karantzelis, G.A. Spyroulias, Z. Lygerou, S. Taraviras. 3D Reconstitution of the Neural Stem Cell Niche: Connecting the Dots. Front. Bioeng. Biotechnol. 9, 705470 (2021). https://doi.org/10.3389/fbioe.2021.705470

Jan 04

82. Development of a novel PTD-mediated IVT-mRNA Delivery Platform for potential Clinical Application as Protein Therapy approach for Metabolic/Genetic disorders. Mol. Ther. Nucleic Acids 26, 694-710 (2021)

82. A.N. Miliotou, I.S. Pappas, G.A. Spyroulias, E. Vlachaki, A.S. Tsiftsoglou, I.S. Vizirianakis, L.C. Papadopoulou. Development of a novel PTD-mediated IVT-mRNA Delivery Platform for potential Clinical Application as Protein Therapy approach for Metabolic/Genetic disorders. Mol. Ther. Nucleic Acids 26, 694-710 (2021). doi: https://doi.org/10.1016/j.omtn.2021.09.008.

Jan 04

81. Gadolinium porphyrinate double-deckers for visible light driven H2. Polyhedron 208, 115421 (2021)

81. E. Nikoloudakis, G. Charalambidis, M. Vasila, E. Orfanos, P. Angaridis, G.A. Spyroulias A.G. Coutsolelos. Gadolinium porphyrinate double-deckers for visible light driven H2. Polyhedron 208, 115421 (2021). doi.org/10.1016/j.poly.2021.115421

Jan 04

80. Non-targeted 1H NMR fingerprinting and multivariate statistical analysis for traceability of Greek PDO Vostizza currants. J.  Food Science 86, 4417-29 (2021)

80. M.-E. Dimitrakopoulou, K. Matzarapi, S.A. Chasapi, A. Vantarakis, G.A. Spyroulias. Non-targeted 1H NMR fingerprinting and multivariate statistical analysis for traceability of Greek PDO Vostizza currants. J.  Food Science 86, 4417-29 (2021). https://doi.org/10.1111/1750-3841.15873

Jan 04

79. 3D cell metabolomics deciphers the anti-angiogenic properties of the radioprotectant amifostine. Cancers, 13, 2877, (2021)

79. Katsila, S.A. Chasapi, J.C. Gomez Tamayo, C. Chalikiopoulou, E. Siapi, G. Moros, P. Zoumpoulakis, G.A Spyroulias, D. Kardamakis. 3D cell metabolomics deciphers the anti-angiogenic properties of the radioprotectant amifostine. Cancers, 13, 2877, (2021). https://doi.org/10.3390/cancers13122877

Jan 04

78. Assessment of ligand binding to the SARS-CoV-2 main protease by saturation transfer difference NMR spectroscopy. J. Biomol. NMR, 75, 167-178, (2021)

78. A.L. Kantsadi, E. Cattermole, M.-T. Matsoukas, G.A. Spyroulias, I. Vakonakis. Assessment of ligand binding to the SARS-CoV-2 main protease by saturation transfer difference NMR spectroscopy. J. Biomol. NMR, 75, 167-178, (2021). https://doi.org/10.1007/s10858-021-00365-x

Jan 04

77. Effect of dapagliflozin on urine metabolome in patients with type 2 diabetes. J. Clin. Endocrinol. Metab. 106, 1269-1283 (2021)

77. E. Bletsa, S. Filippas-Dekouan, C. Kostara, P. Ntafopoulos, A. Dimou, S. Chasapi, G.A. Spyroulias, M. Elisaf, E. Bairaktari, E. Ferrannini, V. Tsimihodimos. Effect of dapagliflozin on urine metabolome in patients with type 2 diabetes. J. Clin. Endocrinol. Metab. 106, 1269-1283 (2021).  https://doi.org/10.1111/dom.13823

Jan 04

76. Large-scale recombinant production of the SARS-CoV-2 proteome for high-throughput and structural biology applications. Front. Mol. Biosci  8, 653148, (2021)

76. A. Gallo, B. Fourkiotis, A.C. Tsika, G.A. Spyroulias & COVID19-NMR consortium. Large-scale recombinant production of the SARS-CoV-2 proteome for high-throughput and structural biology applications. Front. Mol. Biosci  8, 653148, (2021). https://doi.org/10.3389/fmolb.2021.653148

Jan 04

75. The Heat Stability of Rhamnolipid Containing Egg-Protein Stabilised Oil-In-Water Emulsions. Food Hydrocolloids 116, 106632 (2021)

75. Russell, A. Zompra, G.A. Spyroulias, K. Salek, S.R. Euston. The Heat Stability of Rhamnolipid Containing Egg-Protein Stabilised Oil-In-Water Emulsions. Food Hydrocolloids 116, 106632 (2021). https://doi.org/10.1016/j.foodhyd.2021.106632