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Dr. Angelo Gallo

Chemist, MSc, PhD in Structural Biology

Expertise in NMR spectroscopy for biomolecules, Solid-state NMR, solution state NMR, protein-protein interaction, protein-small molecules interaction, protein-metal interactions, pulse programming for NMR, structure calculation, docking and molecular dynamics.

Publications: 19 in peer-reviewed journals

Participation in Funded Projects: PRIN 2009 (Italian Minister of Research), EU-COST action (CA15133) “The Biogenesis of Iron-Sulfur Proteins: from Cellular Biology to Molecular Aspects (FeSBioNet).”, ERC Starting Grant 639907 (2015-2020): Structural Dynamics of Large Protein Complexes under the supervision of Prof J.R. Lewandowski (grant holder).

Current Funding: THE NATIONAL RESEARCH INFRASTRUCTURES ON INTEGRATED STRUCTURAL BIOLOGY, DRUG SCREENING EFFORTS AND DRUG TARGET FUNCTIONAL CHARACTERIZATION – INSPIRED» SUBPROJECT: «INSPIRED-University of Patras» [MIS: 80585/5002550].

Email: angelo.gallo83@gmail.com

Dr. Angelo Gallo is a Post-doctoral Researcher at the Department of Pharmacy holding a Ph.D. degree in Structural Biology from CERM at the University of Florence (IT). He has 10 years of experience on nuclear magnetic resonance (NMR) spectroscopy as a tool in structural biology. He developed high expertise in solution during his PhD and postdoctoral tenure in Florence (IT) and in solid-state NMR in the lab of Prof J R Lewandowski at the University of Warwick (UK). He graduated from University of Trieste in 2005 (Chemistry) and then he joined CERM, at the University of Florence, in 2005, where he obtained his MSc in Chemistry of Biological Molecules under the supervision of the Prof L Banci. He, then, completed his PhD in 2011 with on “Characterization of oxidative folding pathway in mitochondria from single structure to protein-protein interaction” (Supervisor: Prof I Bertini). In 2011, he continued his work as a Postdoctoral Fellow at CERM (Prof. L Banci). In 2015, he joined the lab of Prof J R Lewandowski at Warwick where he contributed to state-of-the-art solution and solid-state NMR spectroscopy method development and application, to molecular dynamics simulations and sophisticated modelling. His recent NMR methodology development work has been recognized by the 2020 Journal of Magnetic Resonance Young Scientist Award. His major research interests cover all aspects of structures of biomolecules through NMR spectroscopy, analysis/physicochemical characterization of biomolecules and their interaction to better understand their function. He is also interested in NMR spectroscopy methods development. He co-authored 19 publications in peer review journals.

Most Important Publications:

  1. “Structural basis for chain release from the enacyloxin polyketide synthase”, S. Kosol, A. Gallo, D. Griffiths, T. R. Valentic, J. Masschelein, M. Jenner, E. L. C. de los Santos, L. Manzi, P. K. Sydor, D. Rea, S. Zhou, V. Fülöp, N. J. Oldham, S.-C. Tsai, G. L. Challis, and J. R. Lewandowski, Nature Chemistry, (2019) 11(10), 913-923.
  2. “A suite of solid-state NMR experiments to utilize orphaned magnetization for assignment of proteins using parallel high and low gamma detection”, Α. Gallo, T. Franks, J. R. Lewandowski, Journal of Magnetic Resonance. (2019) 305, 219-231.
  3. “Functional reconstitution of mitochondrial Fe/S cluster synthesis on Isu1 reveals the involvement of ferredoxin”, H. Webert, S. A. Freibert, A. Gallo, T. Heidenreich, U. Linne, S. Amlacher S, E. Hurt, U. Mühlenhoff, L. Banci, R. Lill, Nature Communications, (2014) 5(1), 1-12.
  4. “Structure of Nucleophosmin DNA-binding Domain and Analysis of Its Complex with a G-quadruplex Sequence from the c-MYC Promoter.”, A. Gallo, C. Lo Sterzo, M. Mori, A. Di Matteo, I. Bertini, L. Banci, M. Brunori, L. Federici, Journal of Biological Chemistry, (2012) 287(32), 26539-48.
  5. “MIA40 is an oxidoreductase that catalyzes oxidative protein folding in mitochondria”, L. Banci, I. Bertini, C. Cefaro, S. Ciofi-Baffoni, A. Gallo, M. Martinelli, D. P. Sideris, N. Katrakili, K. Tokatlidis, Nature Structural & Molecular Biology, (2009) 16(2), 198-206.

Current funding: THE NATIONAL RESEARCH INFRASTRUCTURES ON INTEGRATED STRUCTURAL BIOLOGY, DRUG SCREENING EFFORTS AND DRUG TARGET FUNCTIONAL CHARACTERIZATION – INSPIRED» SUBPROJECT: «INSPIRED-University of Patras» [MIS: 80585/5002550].

ORCID iD: https://orcid.org/0000-0001-9778-4822

SCOPUS Author ID: 35547410600

Web of Science ResearcherID: N-3781-2017

Email: angelo.gallo83@gmail.com