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Dr. Aikaterini I. Argyriou

Pharmacist, MSc, PhD in Pharmacy

Expertise in: Recombinant protein expression (E. Coli), labeling & purification, Large-scale RNA in vitro transcription, Protein-RNA interaction, Peptide Synthesis

Publications: 8 in peer-reviewed journals

Participation in Funded Projects: FP7-NEUROCYPRES, GSRT-THALIS, H2020-MARISURF, EDBM34-ESPA, HFRI-2019, FEBS Short-Term Fellowship, ETH Zurich/Allain Lab 2015.

Current Funding: Post-Doctoral Grant, State Scholarships Foundation (IKY), Greece

Email: argyriou@upatras.gr

Dr. Katerina (Aikaterini) Argyriou, PhD is Research Scientist at the BioNMR Group at the Department of Pharmacy, University of Patras, Greece. She graduated from the Department of Pharmacy of the University of Patras in 2009 and she joined Professor’s Spyroulias Lab in September 2009. In her Master’s and doctoral dissertations, she worked with a variety of different proteins (membrane receptors, RNA binding proteins, Zn-proteins, etc.) with great biological role and different biophysical techniques. Dr. Argyriou is proficient in large scale production, purification/isolation (size-distribution analysis by analytical ultracentrifugation, column chromatography, HPLC/FPLC etc.) and characterization (through UV-visible, CD & NMR spectroscopy) of polypeptides. She also has expertise in NMR labeling techniques such as selective amino acid labeling, specific protonation of methyl-groups and segmental labeling.

Most Important Publications:

  1. “Functional and structural aspects of La overexpression in cancer cells”, A. I. Argyriou, E. G. Kaliatsi, G. Bouras, M. Apostolidi, P. Konstantinidou, A. N. Shaukat, G. A. Spyroulias and C. Stathopoulos, Nucleic Acids Research Cancer, (2020)
  2. “Therapeutic targeting of the soluble guanylate cyclase.”, G. I. Makrynitsa, A. I. Argyriou, A. A. Zompra, G. A. Spyroulias, and S. Topouzis, Current Medicinal Chemistry, (2019) 26 (15), 2730-2747.
  3. “1H, 13C, 15N backbone and side-chain resonance assignment of Nostoc sp. C139A variant of the heme-nitric oxide/oxygen binding (H-NOX) domain.”, A. I. Argyriou, I. I. Alexandropoulos, K. D. Marousis, S. Topouzis, A. Papa Petropoulos, and G. A. Spyroulias, Biomolecular NMR Assignments, (2016) 10 (2), 395-400.
  4. “1H, 13C and 15N Backbone and side-chain resonance assignment of the LAM-RRM1 N-terminal module of La protein from Dictyostelium discoideum.”, A. I. Argyriou, C. T. Chasapis, M. Apostolidi, P. Konstantinidou, D. Bentrop, C Stathopoulos, and G. A. Spyroulias, Biomolecular NMR Assignments, (2015) 9, (2), 303-307.
  5. “Unravelling the Conformational Plasticity of the Extracellular Domain of a Prokaryotic nAChR Homologue in Solution by NMR.”, C. T. Chasapis, A. I. Argyriou, P. Corringer, D. Bentrop, and G. A. Spyroulias, Biochemistry, (2011) Vol. 50, No. 45, pp. 9681-9683

Current funding: Study of the structural and physical-chemical, RNA recognition and binding factors of the Hepatitis-C virus by La protein using NMR Spectroscopy. State Scholarships Foundation (IKY), Greece, October 2019 (Evaluation score: 92,7/100).

Email: argyriou@upatras.gr