Angiotensin I & II
Angiotensin I & II peptides are key factors in Renin-Angiotensin System and are involved in blood pressure regulation. Renin releases the decapeptide Angiotensin-I (Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-OH, AI) from the Angiotensinogen (alpha2-globulin) which then is hydrolyzed by the Angiotensin-I Converting Enzyme (ACE). ACE generates the Angiotensin-II octapeptide through the hydrolytic release of the C-terminal dipeptide His-Leu. The cascade of the reactions that take place to the release and the metabolism of AI & AII comprise an interesting target for medical and pharmacological research. The structure of both Angiotensin peptides have been determined in solution by NMR spectroscopy (PDB: 1N9U & 1N9V).