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Contact details

Georgios A. Spyroulias, PhD.
Department of Pharmacy
University of Patras
Panepistimioupoli-Rion,
GR-26504 Patras, GREECE
Tel:    +30.2610.969950 (office)
+30.2610.969951 (terra silico)
+30.2610.969952 (terra vitro)
Fax:    +30.2610.969950
Email:  G.A.Spyroulias@upatras.gr

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journals
elements

G.A. Spyroulias, P. Cordopatis. Current Inhibition Concepts of Zinc Metallopeptidases involved in Blood Pressure Regulation.
Current Enzyme Inhibition, 1, 29-42, (2005)
 
A.S. Galanis, G.A. Spyroulias, G. Pairas, E. Manessi-Zoupa, P. Cordopatis. Solid Phase Synthesis and Conformational Properties of ACE catalytic site peptides: The basis for a structural study on the enzyme-substrate interaction.
Biopolymers, 76, 512-526, (2004).
 
S.J. Berners-Price, I. Bertini, H.B. Gray, G.A. Spyroulias, P. Turano. The stability of the cytochrome c scaffold as revealed by NMR spectroscopy.
Journal of Inorganic Biochemistry, 98, 814-23, (2004)
 
G.A. Spyroulias, A.S. Galanis, G. Pairas, E. Manessi-Zoupa, P. Cordopatis. Structural Features of Angiotensin-I Converting Enzyme Catalytic Sites: Conformational Studies in Solution, Homology Models and Comparison With Other Zinc Metallopeptidases.
Current Topics in Medicinal Chemistry, 4, 403-429, (2004).
 
A. Tzakos, A. Galanis, G.A. Spyroulias, P. Cordopatis, E. Manessi-Zoupa, I.P. Gerothanassis. Structure-function discrimination of the N- and C- catalytic domains of human angiotensin-converting enzyme: Implications for Cl- activation and peptide hydrolysis mechanisms.
Protein Engineering, 16, 993-1003, (2003).
 
A. Galanis, G.A. Spyroulias, R. Pieratelli, A. Tzakos, A. Troganis, I.P. Gerothanassis, G. Pairas, E. Manessi-Zoupa, P. Cordopatis. Zinc-Binding in Peptide Models of ACE Active Sites studied through 1H NMR & Chemical Shift Perturbation Mapping.
Biopolymers, 69, 244-252, (2003).
 
G.A. Spyroulias, P. Nikolakopoulou, A. Tzakos, I. Gerothanassis, V. Magafa, E. Manessi-Zoupa, P. Cordopatis. Comparison of the Solution Structures of Angiotensin I & II: Implication for Structure-Function Relationship.
Εuropean Journal of Biochemistry, 270, 2163-2173, (2003).
 
A.K. Boudalis, N. Lalioti, G.A. Spyroulias, C.P. Raptopoulou, A. Terzis, A. Bousseksou, V. Tangoulis, J.-P. Tuchagues, S. P. Perlepes. Novel Rectangular [Fe44-OHO)(μ-OH)2]7+ versus “Butterfly” [Fe43-O)2]8+ Core Topology in the FeIII /RCO2-/phen Reaction Systems (R=Me, Ph; phen=1,10-Phenanthroline): Preparation and Properties of [Fe4(OHO)(OH)2(O2CMe)4(phen)4](ClO4)3, [Fe4O2(O2CPh)7(phen)2](ClO4), and [Fe4O2(O2CPh)8(phen)2].
Inorganic Chemistry, 41, 6474-6487, (2002).
 
G.A. Spyroulias, S. Papazacharias, G. Pairas, P. Cordopatis. Monitoring the Structural Consequences of Phe12?DPhe12 and Leu15?Aib15 substitution in h/r Corticotropin Releasing Hormone: Implications for Design of CRH antagonists.
Eur. J. Biochemistry 269, 6009-6019, (2002).
 
G.A. Spyroulias, A.P. Despotopoulos C.P. Raptopoulou, A. Terzis, D. de Montauzon, R. Poilblanc, A.G. Coutsolelos. Comparative Study of Structure-Properties relationship for Novel β-Halogenated Lanthanide Porphyrins and their Nickel and Free Bases Precursors, as a function of number and nature of Halogens atoms.
Inorganic Chemistry, 41, 2648-2659, (2002).
 
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