Hot & Fresh Papers

The NMR study of a protein belonging to the Ligand-Gated Ion Channel family, {Chasapis C. et al. Biochemistry 2011, 79, 142-52}, provides the residue-specific view in the dynamics and conformational exchange behavior of a nAChR homologue. Read more…

Solution structure and dynamics of the core protease domain of anthrax lethal factor {Dalkas GA. et al. Biochemistry 2010, 49, 10767-9}, describes the NMR study of the catalytic core of the Anthrax Lethal Factor in its metal-free form. Read more…

A computational approach to the study of the binding mode of dual ACE/NEP inhibitors {Dimitropoulos N. et al. J Chem Inf Model 2010, 50, 388-396}, aims to elucidate key structural features that govern the binding and/or selectivity of a single compound toward the zinc catalytic sites of the N- and C-domains of ACE NEP for 11 known dual inhibitors (Vasopeptidase Inhibitors). Read more…