Research Highlights

Modelling and NMR studies of Cys-loop receptors ("FP7-Neurocypres") to gain new insights for the structure, dynamics and interaction of Ligand-gated ion channels (LGICs), such as AChR & homologues {Dimitropoulos N. et al. 2011, Chasapis C.T. et al. 2011}.

NMR-driven Structure-Activity studies of proteins involved in Ubiquitination pathway, like Arkadia E3 ubiquitin ligase RING domain {Kandias N. et al. BBRC 2009, Chasapis C.T. et al. 2011}, a positive regulator of TGF-β family signaling.

Conformational Dynamics of Zn-proteases through Computational approaches and NMR studies to investigate the structural basis of the enzyme-substrate binding and selectivity (Angiotensin-I Converting Enzyme (ACE), Anthrax Lethal Factor (ALF) etc.; Dalkas G. et al. 2010, Dimitropoulos N. et al. 2010, Dalkas G. et al. 2009, Papakyriakou A. et al. Biochemistry 2007}.