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Contact details

Georgios A. Spyroulias, PhD.
Department of Pharmacy
University of Patras
Panepistimioupoli-Rion,
GR-26504 Patras, GREECE
Tel:    +30.2610.969950 (office)
+30.2610.969951 (terra silico)
+30.2610.969952 (terra vitro)
Fax:    +30.2610.969950
Email:  G.A.Spyroulias@upatras.gr

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Now is: 2019-10-20 03:06
Angiotensin I & II
Angiotensin I & II peptides are key factors in Renin-Angiotensin System and are involved in blood pressure regulation. Renin releases the decapeptide Angiotensin-I (Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-OH, AI) from the Angiotensinogen (alpha2-globulin) which then is hydrolyzed by the Angiotensin-I Converting Enzyme (ACE). ACE generates the Angiotensin-II octapeptide through the hydrolytic release of the C-terminal dipeptide His-Leu. The cascade of the reactions that take place to the release and the metabolism of AI & AII comprise an interesting target for medical and pharmacological research. The structure of both Angiotensin peptides have been determined in solution by NMR spectroscopy (PDB: 1N9U & 1N9V).