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Contact details

Georgios A. Spyroulias, PhD.
Department of Pharmacy
University of Patras
GR-26504 Patras, GREECE
Tel:    +30.2610.969950 (office)
+30.2610.969951 (terra silico)
+30.2610.969952 (terra vitro)
Fax:    +30.2610.969950
Email:  G.A.Spyroulias@upatras.gr

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Now is: 2019-12-07 23:10
G-protein Coupled Receptors’ peptide ligands

target6Luteinizing hormone-releasing hormone (LHRH) or Gonadotropin Releasing Hormone (GnRH) is a hypothalamic decapeptide (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2) with a key role in the control of mammalian reproduction. It is secreted in pulses from the hypothalamus and stimulates the anterior pituitary gland to release the gonadotropins luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Oncological uses of LHRH analogues are based on the inhibition of the pituitary gonadal function, the suppression of gonadal steroid hormone secretion leading to inhibition of the growth of sex hormone dependent tumors. The NMR solution structures of the native hormone, of the Leuprolide and of a Leuprolide analogue with a non-native residue incorporated to the peptide chain have been determined (PDB: 1YY1 & 1YY2).

Oxytocin is a nonapeptide hormone (Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2) and neurotransmitter, which regulates several physiological functions, as milk ejection, uterine contractions, vascular and cardiac relaxation, interferes with salt and water balance, having also a role in sexual, maternal and social relative behavior. It is generally recognized that, during pregnancy, oxytocin plays a major role in the initiation of both normal and pathologically early deliveries. NMR conformational analysis have been performed for various synthetic peptide analogues.

Completed Projects: CRH, Angiotensins, Somatostatin derrivatives