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Contact details

Georgios A. Spyroulias, PhD.
Department of Pharmacy
University of Patras
GR-26504 Patras, GREECE
Tel:    +30.2610.969950 (office)
+30.2610.969951 (terra silico)
+30.2610.969952 (terra vitro)
Fax:    +30.2610.969950
Email:  G.A.Spyroulias@upatras.gr

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Now is: 2017-09-20 07:30
Copper proteins
Copper (Cu) homeostasis is important for normal cell life and deregulation of copper transport and metabolism pathways are strongly coupled to various  diseases, like Wilson and Menkes diseases {La Fontaine S et al. Arch Biochem Biophys. 463, 149-67 (2007)}. These rare diseases exhibit  remarkably high incidence ratio in certain regions of South-Eastern Greece, like the islands of Kalymnos and Crete, where symptoms of abnormal copper metabolism are normally registered for the12% of newborns, compared to the  standard incidence ratio of Wilson disease which is encountered in 1-3% of  the population.
In order to understand the architecture and the conformational dynamics of proteins and protein assemblies involved In copper delivery for thylakoid import {PNAS 2006, 103, 8320; PDB: 2GCF} and proteins that socialized upon reconstitution of copper center(s), like the one of  the cytochrome’s c oxidase Cu(A) {Nature Chem. Biol. 2008 4, 599;  PDB: 2K6V, 2K6W, 2K6Y, 2K6Z & 2K70}, have been studied using
multinuclear and multidimensional, high resolution, NMR Spectroscopy  in collaboration with  the Center of Magnetic Resonance (CERM) of  University of Florence (Italy).