Contact details
Georgios A. Spyroulias, PhD.
Department of Pharmacy
University of Patras
Panepistimioupoli-Rion,
GR-26504 Patras, GREECE
Tel: +30.2610.969950 (office)
+30.2610.969951 (terra silico)
+30.2610.969952 (terra vitro)
Fax: +30.2610.969950
Email: G.A.Spyroulias@upatras.gr
Site Statistics








![]() | Today | 2634 |
![]() | Yesterday | 2366 |
![]() | This week | 14833 |
![]() | Last week | 16631 |
![]() | This month | 17270 |
![]() | Last month | 71325 |
![]() | All | 1980513 |
Online (20 minutes ago): 48
Your IP: 3.231.229.89
,
Now is: 2019-12-07 23:09
Your IP: 3.231.229.89
,
Now is: 2019-12-07 23:09
Zinc Metalloproteases – Conformational Dynamics and substrate selectivity |
![]() The coordination properties of the zinc allows the metal to bind within a broad range of tetrahedral sites in proteins and its role has found to be among others structural and/or catalytic. Zinc proteins may comprise the 10% of the human proteome with Zinc-metalloproteases being among them. Zn-proteases are enzymes where zinc participates in the proteolysis of peptides or polypeptides. Angiotensin-I Converting Enzyme, Neutral Endopeptidase and Endothelin Converting Enzyme are all enzymes that catalyze the proteolytic cleavage of short peptides (Angiotensin-I, Bradykinin, Endothelin, etc.) that are implicated in blood pressure regulation {Sturrock ED et al. Nat Rev Drug Discov. 2, 891-902, (2003)}. Anthrax Lethal Factor is a highly specific metalloprotease that cleaves most isoforms of the family of mitogen-activated protein kinase kinases (MEKs/MKKs) close to their amino termini, resulting in the inhibition of one or more signaling pathways {Duesbery NS et al. Cancer Res. 68, 81–88, (2008)}. All the above Zn-proteases belong to the gluzincin sub-family. Computational tools and experimental techniques are applied in order to draw atomic-level structural insights from enzyme-peptide/substrate complexes towards the understanding of enzyme selectivity and function. |