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Contact details

Georgios A. Spyroulias, PhD.
Department of Pharmacy
University of Patras
Panepistimioupoli-Rion,
GR-26504 Patras, GREECE
Tel:    +30.2610.969950 (office)
+30.2610.969951 (terra silico)
+30.2610.969952 (terra vitro)
Fax:    +30.2610.969950
Email:  G.A.Spyroulias@upatras.gr

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Now is: 2017-09-21 06:46
Ion channels - Ligand-gated ion channels (LGIC) and Potassium Channels

target4Acetylcholine Receptor is a member of the the Cys-loop receptors (CLRs). These molecules share a generic protein architecture consisting of five subunits with an integral ion-channel that can open and close depending on ligand binding {Tzartos SJ et al. IUBMB Life. 61, 407-423, (2009)}. Apart nicotinic acetylcholine receptor this group of biomolecules includes also the GABAA-, 5HT3-, and Glycine receptors, with all having important roles in central and peripheral nervous system function. Dysfunction of CLRs is linked to muscle disorders (e.g. myasthenic syndromes), hyperexcitabiliy of the brain (e.g. epilepsy) and spinal cord (e.g. hyperekplexia / stiff baby syndrome) as well as nicotine addiction, while CLR subunit genes serve as candidates for frequent psychiatric diseases (e.g. schizophrenia). Moreover, CLRs serve as molecular targets for a functionally diverse group of clinically important drugs, including curare-like muscle relaxants, tranquillizers and anticonvulsants like the benzodiazepines, as well as anti-emetics. Based on the identification of selective CLR subtypes, novel drugs are on the horizon, mediating highly selective therapeutic effects and providing new avenues for therapeutically use. The group performs activities in the study of the conformational dynamics of various nAChR subunits in their free and substrate-bound state and its prokaryotic homologues. For more information please visit the official web site of ‘Neurocypres’ FP7 project.

Completed Projects: Small conductance Ca(2+)-activated K(+) channels