Postgraduate Courses - Informatics on Life Sciences, Depts of Biology, Computer Science, Medicine & Pharmacy
  • Structural Bioinformatics and Biomolecular Simulations
  • Molecular Modeling & Design

topics Covered

  • Structural Bioinformatics, Data bases, searching and data mining,
  • Sequence similarity search and sequence alignment. Use of ClustalW and BLAST algorithm. Applications & examples.
  • Protein Architecture and classification of protein structures. Prediction of Secondary structure elements, algorithms and web-based platforms Molecular Building and Visualization.
  • Applications and examples, use of MolMol software, analysis of various protein structure available in Protein Data Bank (PDB).
  • Conformational analysis of biomolecules, techniques and applications. Solution structure determination, Quality analysis and assessment of biomolecular structures. Applications, use of Procheck software, analysis of Xray models and NMR models ensemble available in PDB.
  • Biomolecular Simulations, Comparative modeling, Fold recognition. Docking simulations and principles in structure-based & computer-aided drug design. Web-based applications, use of SwissModel (homology/comparative modeling) and Phyre (fold recognition) servers