nmrlab

rtrainoprtResearch Training Opportunities

The group offer research training opportunities to Pharmacy, Chemistry, Biology or Medicine under- and post-graduate students who want to get involved in research training activities in the frame of their Diploma Thesis or to acquire a Master or a Ph.D. degree.  Read more…

Students will receive training in the fields of protein expression and characterization, analysis of NMR spectra of peptides and proteins, structure determination of polypeptides using NMR structural information and Biomolecular Simulations and they will work on one of the research projects of the group.

No previous experience is required.  All you need is talent and enthusiasm!
 
NMR model NMR Dynamics In silico complex
The NMR 3D model of the Arkadia E3 Ubiquitin ligase, a RING-H2 Finger domain determined recently and deposited to PDB {Chasapis C. et al. 2010}. See more...

NMR characterization of the ECD of a prokaryotic LGIC elucidates the regions of the protein that may affect oligomerization{Chasapis C.T. et al. 2011}. Read more

In silico biomolecular complex of a1 nAChR bound to two toxins (a-bungarotoxin & a-cobratoxin) {Dimitropoulos N. et al. PROTEINS 2011, 79, 142-52}. Read more...

NMR meeting in GREECE
EUROMAR 2013 in GREECE Editorial
EAST-NMR Event & GREEK NMR Users meeting organized at 19th September 2011, Athens. New NMR hardware, techniques and methodologies were presented Read more…

EUROMAR 2013 will be held at Greece (Hersonissos, Crete) and will provide a unique opportunity for Greek NMR community to meet NMR experts from all over the world, (1st week of July, 2013). Read more

 

Bentham Sci. "Current Pharmaceutical Design" has published a Special Issue with 9 articles on the Latest Achievements on Zn-enzymes (2009; Vol 15, Issue 31). Read more…

 

 

Research Highlights

Modelling and NMR studies of Cys-loop receptors ("FP7-Neurocypres") to gain new insights for the structure, dynamics and interaction of Ligand-gated ion channels (LGICs), such as AChR & homologues {Dimitropoulos N. et al. 2011, Chasapis C.T. et al. 2011}.

NMR-driven Structure-Activity studies of proteins involved in Ubiquitination pathway, like Arkadia E3 ubiquitin ligase RING domain {Kandias N. et al. BBRC 2009, Chasapis C.T. et al. 2011}, a positive regulator of TGF-β family signaling.

Conformational Dynamics of Zn-proteases through Computational approaches and NMR studies to investigate the structural basis of the enzyme-substrate binding and selectivity (Angiotensin-I Converting Enzyme (ACE), Anthrax Lethal Factor (ALF) etc.; Dalkas G. et al. 2010, Dimitropoulos N. et al. 2010, Dalkas G. et al. 2009, Papakyriakou A. et al. Biochemistry 2007}.

 

Hot & Fresh Papers

The NMR study of a protein belonging to the Ligand-Gated Ion Channel family, {Chasapis C. et al. Biochemistry 2011, 79, 142-52}, provides the residue-specific view in the dynamics and conformational exchange behavior of a nAChR homologue. Read more…

Solution structure and dynamics of the core protease domain of anthrax lethal factor {Dalkas GA. et al. Biochemistry 2010, 49, 10767-9}, describes the NMR study of the catalytic core of the Anthrax Lethal Factor in its metal-free form. Read more…

A computational approach to the study of the binding mode of dual ACE/NEP inhibitors {Dimitropoulos N. et al. J Chem Inf Model 2010, 50, 388-396}, aims to elucidate key structural features that govern the binding and/or selectivity of a single compound toward the zinc catalytic sites of the N- and C-domains of ACE NEP for 11 known dual inhibitors (Vasopeptidase Inhibitors). Read more…